Our AI models learn to generate therapeutic molecules with improved properties by training on natural and experimentally-derived data. Acquiring data relevant to function at scale is a critical step in maximizing the performance of our models. We think broadly about the type and scale of data necessary to improve our models, then identify or invent the methods needed to acquire that data.

You will be responsible for the development and deployment of novel high-throughput assays to measure various properties of large sequence libraries. You will use a data-driven approach to optimize assays and apply chemical and biological insights to maximize the utility of information collected. You will apply this data to efficiently improve design of therapeutic molecules in close collaboration with biologists, ML and data engineers, and translational experts.

Responsibilities

• Embody our vision of an interdisciplinary environment and embrace learning about areas outside of your traditional area of expertise

• Collaborate with team members from diverse backgrounds to create experiments that creatively leverage biology and computation

• Develop and execute pooled assays to measure sequence-to-function in vitro, in cells, and in vivo

• Generate, analyze, and communicate data that maximally impacts AI-based molecular design

Qualifications

• PhD and 4+ years of post-PhD experience (e.g., startup, industry, or research)

• Problem-solver who combines deep knowledge of experimental methods with quantitative intuition to generate biological data at and beyond the state-of-the-art

• Solid foundation in theory and techniques of molecular and cellular biology

• History of building highly multiplexed assays to generate rich datasets from mammalian cells, such as large functional screens or single-cell 'omics

• Scientific programming (preferably in Python), including analysis and visualization of complex data

• Availability to work with team members across US and Europe, with meetings starting at 8am PT

• Readiness to travel several times a year for company retreats and business events

• We value in-person collaboration and expect candidates to work at our lab location

Preferred skills

• Experience with mammalian synthetic biology, particularly for cell therapy applications

• Knowledge of RNA biology, biochemistry, and biologics drug development

• Strong understanding of next-generation sequencing platforms (Illumina, Oxford Nanopore, Pac Bio), including library preparation and data analysis

• Experience generating and analyzing large 'omics datasets, via sequencing and/or mass spectrometry

Compensation

$135K – $240K + Bonus + Equity

What we offer

• A competitive compensation package

• 30 days paid vacation per year

• Comprehensive health insurance for US based Beginners

• 401K with company match for US based Beginners and Direktversicherung for German Beginners

• Quarterly company-wide retreats

• Monthly wellness benefit

• Budget for multiple visits per year to our offices in Berlin, Palo Alto or Switzerland

• Learning & Development budget to attend conferences, take courses, or otherwise invest in your professional growth, as well as access to the Learning & Development platform EdX and Hone

• A buddy to help you get settled

*Varies by country and does not apply to internships

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You will work at the intersection of AI safety and CBRN security, conducting thorough investigations into potential misuse cases, developing novel detection techniques, and building robust defenses against threat actors who may attempt to leverage our AI technology for developing weapons, synthesizing dangerous compounds, or creating biological harm.

Important context: In this position you may be exposed to explicit content spanning a range of topics, including those of a sexual, violent, or psychologically disturbing nature. This role may require responding to escalations during weekends and holidays.

Responsibilities:

• Detect and investigate attempts to misuse Anthropic's AI systems for developing, enhancing, or disseminating CBRN-E weapons, pathogens, toxins, or other threats to harm people, critical infrastructure, or the environment

• Conduct technical investigations using SQL, Python, and other tools to analyze large datasets, trace user behavior patterns, and uncover sophisticated CBRN-E threat actors

• Develop CBRN-E-specific detection capabilities, including abuse signals, tracking strategies, and detection methodologies tailored to dual-use research concerns

• Create actionable intelligence reports on CBRN-E attack vectors, vulnerabilities, and threat actor TTPs leveraging AI systems

• Conduct cross-platform threat analysis grounded in real threat actor behavior, open-source research, and publicly reported programs

• Collaborate with policy and enforcement teams to make informed decisions about user violations and ensure appropriate mitigation actions

• Engage with external stakeholders including government agencies, regulatory bodies, scientific organizations, and biosecurity/chemical security research communities

• Inform safety-by-design strategies by forecasting how threat actors may leverage advances in AI technology for CBRN-E purposes

You may be a good fit if you

• Have deep domain expertise in biosecurity, chemical defense, biological weapons non-proliferation, dual-use research of concern (DURC), synthetic biology, or related CBRN-E threat domains

• Have demonstrated proficiency in SQL and Python for data analysis and threat detection

• Have experience with threat actor profiling and utilizing threat intelligence frameworks

• Have hands-on experience with large language models and understanding of how AI technology could be misused for CBRN-E threats

• Have excellent stakeholder management skills and ability to work with diverse teams including researchers, policy experts, legal teams, and external partners

• Can present analytical work to both technical and non-technical audiences, including government stakeholders and senior leadership

Strong candidates may also have

• Advanced degree (MS or PhD) in biological sciences, chemistry, biodefense, biosecurity, or related field

• Real-world experience countering weapons of mass destruction or other high-risk asymmetric threats

• Experience working with government agencies or in regulated environments dealing with sensitive CBRN-E information

• Background in AI safety, machine learning security, or technology abuse investigation

• Familiarity with synthetic biology, biotechnology, or dual-use research

• Experience building and scaling threat detection systems or abuse monitoring programs

• Active Top Secret security clearance

The annual compensation range for this role is $230,000-$290,000 USD.

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The base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. If the role is non-exempt, overtime pay will be provided consistent with applicable laws. In addition to the salary range listed above, total compensation also includes generous equity, performance-related bonus(es) for eligible employees, and the following benefits.

• Medical, dental, and vision insurance for you and your family, with employer contributions to Health Savings Accounts

• Pre-tax accounts for Health FSA, Dependent Care FSA, and commuter expenses (parking and transit)

• 401(k) retirement plan with employer match

• Paid parental leave (up to 24 weeks for birth parents and 20 weeks for non-birthing parents), plus paid medical and caregiver leave (up to 8 weeks)

• Paid time off: flexible PTO for exempt employees and up to 15 days annually for non-exempt employees

• 13+ paid company holidays, and multiple paid coordinated company office closures throughout the year for focus and recharge, plus paid sick or safe time (1 hour per 30 hours worked, or more, as required by applicable state or local law)

• Mental health and wellness support

• Employer-paid basic life and disability coverage

• Annual learning and development stipend to fuel your professional growth

• Daily meals in our offices, and meal delivery credits as eligible

• Relocation support for eligible employees

• Additional taxable fringe benefits, such as charitable donation matching and wellness stipends, may also be provided.

About the Team

OpenAI’s mission is to ensure that general-purpose artificial intelligence benefits all of humanity. We believe that achieving our goal requires real world deployment and iteratively updating based on what we learn.

The Intelligence and Investigations team supports this by identifying and investigating misuses of our products – especially new types of abuse. This enables our partner teams to develop data-backed product policies and build scaled safety mitigations. Precisely understanding abuse allows us to safely enable users to build useful things with our products.

About the Role

As an Abuse Investigator on the Intelligence and Investigations team, you will be responsible for detecting misuse of our platform or services. Specifically, you will focus on cases where users attempt to use our platform in connection with prohibited activities such as developing or delivering biological and/or chemical threats to harm people, critical resources/infrastructure, or the environment. OpenAI has strict prohibitions and policies in this area, and you will detect, disrupt, and enforce on actors who violate our policies.

This role requires domain-specific expertise, experience investigating sophisticated threats, and the ability to navigate ambiguous signals in a complex and adversarial threat environment.

You will respond to time-sensitive escalations and will be expected to present your investigative work, both in writing and verbally, to key stakeholders across government, industry, and civil society, when required. You will also help inform the company’s evolving threat response and integrity monitoring and mitigation stack, while working closely on individual cases and enforcement assessments.

In this role, you will:

• Detect, investigate, and disrupt the attempted misuse of OpenAI products for the development or dissemination of biological threats, including dual-use misuse and emerging biothreat vectors. You will also be expected to work across related domains (e.g., chemical threats).

• Partner closely with teams across Policy, Legal, Integrity, Global Affairs, and Security to conduct robust investigations, including cross-internet and open-source research to trace and understand abuse and ensure OpenAI’s mitigations address evolving needs in the space.

• Develop abuse signals and tracking strategies to proactively detect users attempting dual-use or biohazard-related misuse of our platform and review content for enforcement decisions.

• Communicate findings from your investigations with internal stakeholders and leadership and, at times, external partners including regulatory or scientific organizations.

• Develop a categorical understanding of our product surfaces in the biosecurity space, and work with teams to improve data visibility and internal tooling.

You might thrive in this role if you:

• Have industry-leading experience in biosecurity, biological weapons non-proliferation, dual-use research of concern (DURC), or related biodefense fields,

• Have strong familiarity with technical investigations, especially using SQL and Python, in a government/military and/or tech company

• Have demonstrated experience in risk-mitigation (e.g., adversarial thinking and record of success in threat mitigation)

• Have worked on investigations related to biological threat actors, malicious dual-use exploitation, or responsible innovation in synthetic biology or bioengineering

• Have at least 5+ years of experience tracking misuse and/or abuse in biosecurity or life sciences domains, or equivalent education in these domains

• Have at least 2 years of experience developing innovative detection solutions and conducting open-ended research to solve real-world problems

• Experience in presenting analytical work in public or policy settings

• Have experience scaling and automating processes, especially with language models

About OpenAI

OpenAI is an AI research and deployment company dedicated to ensuring that general-purpose artificial intelligence benefits all of humanity. We push the boundaries of the capabilities of AI systems and seek to safely deploy them to the world through our products. AI is an extremely powerful tool that must be created with safety and human needs at its core, and to achieve our mission, we must encompass and value the many different perspectives, voices, and experiences that form the full spectrum of humanity.

We are an equal opportunity employer, and we do not discriminate on the basis of race, religion, color, national origin, sex, sexual orientation, age, veteran status, disability, genetic information, or other applicable legally protected characteristic.

For additional information, please see [OpenAI’s Affirmative Action and Equal Employment Opportunity Policy Statement](https://cdn.openai.com/policies/eeo-policy-statement.pdf).

Background checks for applicants will be administered in accordance with applicable law, and qualified applicants with arrest or conviction records will be considered for employment consistent with those laws, including the San Francisco Fair Chance Ordinance, the Los Angeles County Fair Chance Ordinance for Employers, and the California Fair Chance Act, for US-based candidates. For unincorporated Los Angeles County workers: we reasonably believe that criminal history may have a direct, adverse and negative relationship with the following job duties, potentially resulting in the withdrawal of a conditional offer of employment: protec

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We are looking for a Technical CBRN-E Threat Investigator to join our Threat Intelligence team. In this role, you will be responsible for detecting, investigating, and disrupting the misuse of Anthropic's AI systems for Chemical, Biological, Radiological, Nuclear, and Explosives (CBRN-E) threats.

Responsibilities

• Detect and investigate attempts to misuse Anthropic's AI systems for developing, enhancing, or disseminating CBRN-E weapons, pathogens, toxins, or other threats to harm people, critical infrastructure, or the environment

• Conduct technical investigations using SQL, Python, and other tools to analyze large datasets, trace user behavior patterns, and uncover sophisticated CBRN-E threat actors

• Develop CBRN-E-specific detection capabilities, including abuse signals, tracking strategies, and detection methodologies tailored to dual-use research concerns

• Create actionable intelligence reports on CBRN-E attack vectors, vulnerabilities, and threat actor TTPs leveraging AI systems

• Conduct cross-platform threat analysis grounded in real threat actor behavior, open-source research, and publicly reported programs

• Collaborate with policy and enforcement teams to make informed decisions about user violations and ensure appropriate mitigation actions

• Engage with external stakeholders including government agencies, regulatory bodies, scientific organizations, and biosecurity/chemical security research communities

• Inform safety-by-design strategies by forecasting how threat actors may leverage advances in AI technology for CBRN-E purposes

You may be a good fit if you

• Have deep domain expertise in biosecurity, chemical defense, biological weapons non-proliferation, dual-use research of concern (DURC), synthetic biology, or related CBRN-E threat domains

• Have demonstrated proficiency in SQL and Python for data analysis and threat detection

• Have experience with threat actor profiling and utilizing threat intelligence frameworks

• Have hands-on experience with large language models and understanding of how AI technology could be misused for CBRN-E threats

• Have excellent stakeholder management skills and ability to work with diverse teams including researchers, policy experts, legal teams, and external partners

Strong candidates may also have

• Advanced degree (MS or PhD) in biological sciences, chemistry, biodefense, biosecurity, or related field

• Real-world experience countering weapons of mass destruction or other high-risk asymmetric threats

• Experience working with government agencies or in regulated environments dealing with sensitive CBRN-E information

• Background in AI safety, machine learning security, or technology abuse investigation

• Familiarity with synthetic biology, biotechnology, or dual-use research

• Experience building and scaling threat detection systems or abuse monitoring programs

• Active Top Secret security clearance

Logistics

• Education requirements: We require at least a Bachelor's degree in a related field or equivalent experience.

• Location-based hybrid policy: Currently, we expect all staff to be in one of our offices at least 25% of the time. However, some roles may require more time in our offices.

• Visa sponsorship: We do sponsor visas! However, we aren't able to successfully sponsor visas for every role and every candidate. But if we make you an offer, we will make every reasonable effort to get you a visa, and we retain an immigration lawyer to help with this.

We encourage you to apply even if you do not believe you meet every single qualification. Not all strong candidates will meet every single qualification as listed. Research shows that people who identify as being from underrepresented groups are more prone to experiencing imposter syndrome and doubting the strength of their candidacy, so we urge you not to exclude yourself prematurely and to submit an application if you're interested in this work.

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