At AstraZeneca, we work together to deliver innovative medicines to patients across global boundaries. This is an opportunity to further develop your pharmacovigilance (PV) experience in safety programs, spanning the entire life cycle of drug development and peri-/post-submission.

Our Scientists and Physicians play a strategic role in developing our medicines and the safety science of the program. AstraZeneca's oncology pipeline, which includes novel combinations and modalities, provides an intellectual challenge to the safety teams, requiring a broad portfolio and scientific management approach to projects.

We are looking for an Associate Director, Senior Patient Safety (PS) Scientist to join our Patient Safety department, working in the Oncology Therapeutic Area. In this exciting and challenging role, you will work collaboratively with the Global Safety Physician (GSP) and other PV Scientists and physicians.

As an Associate Director, Senior Patient Safety Scientist, you will be involved in aggregating, reviewing, analyzing and interpreting safety-related data to generate information to support safety decision-making by prescribers, patients and payers, with the ultimate goal of protecting patients.

You will apply your PV, oncology and scientific experience, knowledge and skills to deliver all aspects of safety documentation, including authoring and/or providing strategic safety input to regulatory documents, e.g., regulatory reports, health authority responses and the safety content of marketing authorization applications.

Patient Safety sits within the Chief Medical Office, where we have a crucial role to play. This is an exciting period for us, as well as for those poised to join us. Our strategy and ability to transform our medicines portfolio means we have a drug-development pipeline that presents incredible opportunities to push the boundaries of science to deliver life-changing medicines.

Minimum Education, Experience and Skill Requirements:

• A Bachelor's in sciences/pharmacy/nursing degree or related field
• Minimum of 3+ years of validated experience
• Patient Safety and/or Clinical/Drug Development proven experience working in safety &/or scientific activities in at least 3 of the following areas:

Clinical drug development (Early and/or Late Phase: develop & deliver program level safety strategy, including proactive risk identification & mitigation planning) Post-Marketing Surveillance (including signal detection & evaluation) MAA/BLA submissions (preparation and authoring of the safety related aspects of the Common Technical Document) Periodic Safety Reports (deliver strategy, preparation and authoring) Risk Management Plans (deliver strategy, preparation and authoring) Governance board interactions and communication across a range of activities

• Good knowledge of PV regulations
• Demonstrated ability to handle more than one activity simultaneously, prioritizing well and recognizing key issues
• Ability to work effectively in an advanced matrix structure
• Proficient in written and verbal English

Preferred Education, Experience and Skills:

• MSc/PhD/PharmD in scientific field
• 2+ years of relevant experience
• Understanding of epidemiology

Pay Transparency: The annual base pay (or hourly rate of compensation) for this position ranges from $132,873.60 - $199,310.40.

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This role will report to the Vice President Clinical Respiratory.

Key responsibilities include:

• Providing clinical and medical expertise input into overall project strategy

• Having accountability for the clinical deliverables i.e. clinical studies, clinical components of regulatory submissions etc to time

• Serving as the single point of contact for TA-Heads and R&D leaders for clinical and scientific components of the product and/or indications

Essential qualifications include:

• An MD, or other equivalent medical degree from an accredited university with specialty training in Respiratory or related area

• 7 years’ relevant experience within the respiratory space, including late-phase drug development experience

• Demonstrated deep clinical and research expertise in appropriate disease area

• Significant hands-on late phase clinical drug development experience

• Developed/delivered multiple complex and large studies (e.g., including but not limited to multinational outcome studies)

• Scientific credibility internally and externally

• Demonstrated success in influencing functions outside of clinical and across geographies

• Experience of benefit/risk assessment and creating patient risk management plans

• Experience of global regulatory submissions and interacting with major regulatory agencies

• Demonstrated ability to successfully lead, coach, and mentor other physicians/scientists

• Proven teamwork and collaboration skills in a global setting

• Credible in scientific and commercial environments

• Fit for purpose business acumen, and insight into payer and reimbursement hurdles globally

• Line management experience

Desirable qualifications include:

• Global external awareness within the therapeutic area

• Global regulatory awareness

• Ability to travel nationally and internationally

• Experience in several organizations and geographic locations

• Experience of working with Market Companies to deliver studies/projects

• Experience of clinical/commercial interface

Join AstraZeneca in our journey of building a new kind of organization to reset expectations of what a biopharmaceutical company can be. We are committed to delivering life-changing medicines and making a positive impact on people's lives.

The annual base salary for this position ranges from $331,873 - $497,810. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.

In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program.

Benefits offered include a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans.

Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment.

If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

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The Compliance Department at Millennium is responsible for adopting, implementing, and administering a comprehensive compliance program, including policies and procedures, processes, systems, controls, surveillance, testing, and reporting, designed to prevent, detect, and address violations of applicable laws, rules, regulations, and Firm policies.

Day-to-day, the Compliance Officer will be instrumental in managing the Firm's responses to formal inquiries, examinations, and reviews from regulatory authorities and self-regulatory organisations applicable to Millennium's business, including the SEC, CFTC, NFA, CME, and other brokers, exchanges or regulators.

Your primary focus will be serving as the central coordination point for regulatory matters affecting Millennium's registered investment adviser and commodity pool operator businesses. You will act as the primary liaison between the Firm and regulators, oversee document productions and written responses, coordinate internal reviews and investigations, and partner closely with Legal, Risk, Operations, Finance, and business stakeholders to ensure timely, accurate, and well-supported regulatory submissions.

Ideal candidates should have experience working in compliance, regulatory examinations, investigations, or enforcement response within an SEC-registered investment adviser, commodity pool operator, hedge fund, or other highly regulated financial institution.

Responsibilities

• Assist in managing the Firm's responses to regulatory inquiries, examinations, reviews, and requests from the SEC, CFTC, NFA, CME, and other applicable brokers, regulators, exchanges, and self-regulatory organisations.

• Serve as a primary liaison between the Firm and regulators, coordinating communications, tracking requests, and ensuring timely and accurate submissions.

• Coordinate internal investigations and fact-finding reviews in response to regulatory inquiries, potential compliance issues, and other escalated matters.

• Gather, review, and organise materials for regulatory productions, including policies and procedures, trading records, communications, surveillance results, marketing materials, books and records, and other supporting documentation.

• Draft and assist in drafting regulatory responses, correspondence, chronologies, briefing materials, and other written submissions.

• Partner with Legal, Risk, Operations, Finance, Technology, and business personnel to assess issues, collect information, and develop appropriate responses and remediation plans.

• Support onsite and remote examinations, including preparation of document productions, interview coordination, meeting logistics, and follow-up requests.

• Track regulatory deadlines, information requests, examination findings, and remediation items to ensure prompt escalation and completion.

• Analyse examination findings, deficiency letters, and investigative requests and assist in developing corrective actions, enhancements to controls, and other risk-mitigating measures.

• Help maintain policies, procedures, and internal protocols related to regulatory engagement, examination readiness, escalation, and recordkeeping.

• Advise relevant stakeholders on regulatory expectations, examination preparedness, and best practices for managing regulatory interactions.

• Maintain accurate and organised books and records relating to regulatory inquiries, examinations, investigations, and related compliance matters.

• Undertake special compliance-related projects and other responsibilities as assigned.

Qualifications/Skills Required

• Bachelor's degree in Finance, Economics, Accounting, Business, or a related field is preferred, with a strong academic record.

• 5+ years of relevant experience in compliance, legal/compliance investigations, regulatory examinations, or enforcement response at an SEC-registered investment adviser, commodity pool operator, hedge fund, broker-dealer, FCM, or similar financial institution.

• Experience managing or supporting responses to regulatory inquiries, examinations, or investigations involving the SEC, CFTC, NFA, CME, or other relevant regulators and exchanges.

• Strong knowledge of the U.S. regulatory framework applicable to investment advisers, private funds, commodity pools, and derivatives trading activity.

• Familiarity with regulatory expectations relating to books and records, supervision, communications, trading activity, policies and procedures, and control frameworks.

• Exceptional written, analytical, and research skills, with the ability to synthesise complex information and prepare clear, concise, and well-supported regulatory responses.

• Strong attention to detail, organisation, and effective communication skills, both verbal and written.

• Ability to work effectively and independently with all levels of management and staff across multiple functions.

• Ability to manage several matters simultaneously and perform effectively under pressure in a fast-paced environment.

• Sound judgment, professionalism, and discretion in handling highly sensitive and confidential matters.

• Proficient to advanced computer skills including MS Outlook, Word, Excel, and PowerPoint; experience with compliance, document management, and e-discovery tools is a plus.

Preferred Qualifications

• Prior experience acting as a direct point of contact with regulators during examinations or investigations.

• Familiarity with hedge fund trading strategies, private fund structures, and operational processes across investment management businesses.

• Experience supporting remediation efforts, issue management, and enhancements to compliance controls arising from regulatory findings.

• Industry licenses or certifications are a plus.

Experience Level: senior Employment Type: full-time Workplace Type: onsite Category: Finance Industry: Finance Salary Range: $70,000 to $160,000 Salary Min: 70000 Salary Max: 160000 Salary Currency: USD Salary Period: year Required Skills:

• Compliance
• Regulatory examinations
• Investigations
• Enforcement response
• Document production
• Written responses
• Internal reviews
• Investigations
• Regulatory submissions
• Legal
• Risk
• Operations
• Finance
• Business
• Stakeholder management
• Communication
• Organisation
• Attention to detail
• Time management
• Pressure management
• Discretion
• Confidentiality
• Computer skills

Preferred Skills:

• Direct point of contact with regulators
• Hedge fund trading strategies
• Private fund structures
• Operational processes
• Remediation efforts
• Issue management
• Compliance controls

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The successful candidate will be responsible for supporting Second Line of Defence Risk Stewardship, including advising on compliance matters, monitoring activities, providing effective review and challenge on business operations, initiatives, and state of controls, and engaging on various aspects of core compliance disciplines for the EQD business, such as licensing/registrations, policies and procedures, training, conflicts, and supervision.

The role requires making commercial decisions while considering regulatory compliance risks/obligations and working to ensure that the business operates within the HSBC risk framework. Collaboration with business management and other functions, such as Non-Financial Risk, COO, Operations, and Technology, is essential to ensure that best practices are in place to facilitate the success of HSBC's business operations and commercial objectives.

Operational effectiveness and control are key aspects of the role, as is ensuring that the business adheres to industry standards and continuously innovates and improves methodologies to meet required standards and regulations. Leadership and teamwork are vital components of the role, as the compliance officer promotes a high-performance culture through collaboration and effective interaction.

Key responsibilities include:

• Providing support to the EQD business by advising and guiding on compliance-related matters, as well as providing support in the same manner, to the wider Equities business locally and globally, as necessary and appropriate.
• Assisting on matters concerning business policies and procedures, regulatory matters including new rule proposals, existing and new equities-related products as well as operational, technological, and other issues in the business.
• Proactively working with business management, Non-Financial Risks, other stakeholders, and compliance officers to ensure best practices and systems are in place to facilitate sound business operations and the overall success of HSBC.
• Responsible for compliance reports, governance submissions, compliance reviews, projects and training efforts, as required.
• Responsible for carrying out projects with regulatory or substantial business impact.
• Building strong relationships, adopting a joined-up approach, to execute processes at pace and with minimum conflict.
• Ensuring that internal and external regulatory requirements are met, including interaction with regulators, as necessary and appropriate.
• Ensuring that the business operates using accepted industry standard methodologies, practices, processes and principles.
• Innovation and improvement of methodologies, through adoption of best practice and continued professional development and ensuring these meet required standards and regulations
• Drive and support a high-performance culture by delivering standards, fostering collaboration, and encouraging effective interactions.
• Agree responsibilities within formal and informal network, providing context, direction and confidence to deliver results.
• Collaborate with other business partners and Global Functions to ensure commonality and consistency of solutions.

The ideal candidate will have:

• A Bachelor's degree – ideally in finance, economics, or a related field
• Extensive experience in a bank or broker-dealer, with a focus on equities markets, specifically equity derivatives – and be able to understand, interpret and apply complex regulatory requirements to business practices.
• Exceptional knowledge of equities markets including trading system and technologies, rules and regulations, risks, and other core aspects in the domain.
• Well-developed managerial, communications, negotiation, analytical, organisational, project management, and strategic and/or operational planning skills.
• Minimum of a bachelor's degree in business, related field or equivalent experience; Master's degree and/or Juris Doctorate (JD) preferred.
• Ability to meet deadlines in a timely manner and deliver effective presentations
• Proactive and independent – seeking a thought leader.
• Proficiency with computers and software packages including Microsoft Excel, Word, and PowerPoint

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You will also be an integral part of achieving industry-leading end-to-end performance benchmarking publications: If MLPerf (Training & Inference), Working closely with NVIDIA (Megatron-LM, TensorRT-LLM & DGX cloud) and the open-source community (llm-d, vLLM and all popular ML frameworks) speak to you, come help us demonstrate CoreWeave's performance reliability leadership in the field.

Responsibilities

• Strategy & Leadership - Define the multi-year benchmarking strategy and roadmap; prioritize models/workloads (LLMs, diffusion, vision, speech) and hardware tiers. Build, lead, and mentor a high-performing team of performance engineers and data analysts. Establish governance for claims: documented methodologies, versioning, reproducibility, and audit trails.

• Perf Ownership - Lead end-to-end MLPerf Inference and Training submissions: workload selection, cluster planning, runbooks, audits, and result publication. Coordinate optimization tracks with NVIDIA (CUDA, cuDNN, TensorRT/TensorRT-LLM, Triton, NCCL) to hit competitive results; drive upstream fixes where needed.

• Internal Latency & Throughput Benchmarks - Design a Kubernetes-native, repeatable benchmarking service that exercises CoreWeave stacks across SUNK (Slurm on Kubernetes), Kueue, and Kubeflow pipelines. Measure and report p50/p95/p99 latency, jitter, tokens/s, time-to-first-token, cold-start/warm-start, and cost-per-token/request across models, precisions (BF16/FP8/FP4), batch sizes, and GPU types. Maintain a corpus of representative scenarios (streaming, batch, multi-tenant) and data sets; automate comparisons across software releases and hardware generations.

• Tooling & Automation - Build CI/CD pipelines and K8s controllers/operators to schedule benchmarks at scale; integrate with observability stacks (Prometheus, Grafana, OpenTelemetry) and results warehouses. Implement supply-chain integrity for benchmark artifacts (SBOMs, Cosign signatures).

• Cross-functional & Community - Partner with NVIDIA, key ISVs, and OSS projects (vLLM, Triton, KServe, PyTorch/DeepSpeed, ONNX Runtime) to co-develop optimizations and upstream improvements. Support Sales/SEs with authoritative numbers for RFPs and competitive evaluations; brief analysts and press with rigorous, defensible data.

Requirements

• 10+ years building distributed systems or HPC/cloud services, with deep expertise on large-scale ML training or similar high-performance workloads.

• Proven track record of architecting or building planet-scale data systems (e.g., telemetry platforms, observability stacks, cloud data warehouses, large-scale OLAP engines).

• Deep understanding of GPU performance (CUDA, NCCL, RDMA, NVLink/PCIe, memory bandwidth), model-server stacks (Triton, vLLM, TensorRT-LLM, TorchServe), and distributed training frameworks (PyTorch FSDP/DeepSpeed/Megatron-LM).

• Proficient with Kubernetes and ML control planes; familiarity with SUNK, Kueue, and Kubeflow in production environments.

• Excellent communicator able to interface with executives, customers, auditors, and OSS communities.

Nice to have

• Experience with time-series databases, log-structured merge trees (LSM), or custom storage engine development.

• Experience running MLPerf submissions (Inference and/or Training) or equivalent audited benchmarks at scale.

• Contributions to MLPerf, Triton, vLLM, PyTorch, KServe, or similar OSS projects.

• Experience benchmarking multi-region fleets and large clusters (thousands of GPUs).

• Publications/talks on ML performance, latency engineering, or large-scale benchmarking methodology.

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This role ensures brake and clutch components are machined safely, efficiently, and in full compliance with engineering specifications and customer quality standards. The technician plays a critical role in new product introduction (NPI), engineering changes, and automotive quality compliance.

Key Responsibilities

CNC Program Prove-Out & Optimization

Prove out new CNC programs on multi-axis machining centres (mainly 5axis) Set up first-article and initial sample runs Validate tooling, fixtures, work holding, offsets, and program parameters Identify and correct programming errors or interference risks Make CAM toolpath adjustments and strategy improvements in hyperMILL Optimize feeds, speeds, and tool engagement for cast iron and aluminium components Reduce cycle time while maintaining dimensional stability and surface finish quality

ISIR / Quality Validation

Ensure first-run parts meet ISIR requirements before production release Verify all dimensions, tolerances, and GD&T callouts per engineering drawings Support dimensional layout inspections using precision measuring tools. Collaborate with Quality to compile inspection data and resolve non-conformances Address root causes of dimensional variation, surface defects, or process instability Implement corrective actions prior to customer submission

Continuous Improvement & Production Support

Troubleshoot machining issues (chatter, runout, tool wear, thermal growth) Improve process repeatability and performance Document setup sheets, tooling lists, and process revisions Provide feedback to Production Engineers about improvements Train operators on finalized programs and standardized setups Reduce scrap, rework, and downtime

Required Qualifications

3–5+ years of CNC machining experience in a production environment Experience proving out CNC programs for precision-machined components Hands-on experience supporting ISIR or PPAP submissions Working knowledge of G-code and M-code Experience making CAM adjustments in hyperMILL Strong understanding of GD&T and drawing interpretation Experience machining cast iron and aluminium components

Preferred Skills

Experience in automotive brake or clutch component manufacturing Multi-axis machining experience Familiarity with low-volume manufacturing environments Root cause analysis and corrective action experience Good communication skills

Hours

Monday – Thursday 8am – 5pm and Friday 8am – 1pm.

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