This role is ideally suited for a physician or pharmacist with deep expertise in pulmonary medicine and experience across late-stage development, launch readiness, and post-approval medical excellence. The Medical Director ensures US medical strategy is aligned with global direction while remaining responsive to the healthcare and clinical landscape within the United States.

At AstraZeneca, teams work across global boundaries to make an impact and find answers to complex challenges. This role sits at the heart of that mission, combining scientific depth with strategic leadership to advance care in chronic respiratory disease.

This position completes the medical strategy and carries out the execution for a novel Interleukin-33 targeting monoclonal antibody, crafting both product and disease area direction across the full lifecycle.

Reporting directly to the US Medical Head, COPD Biologics, this leader will guide a high-performing team, drive launches, and influence how evidence, access, and clinical practice come together to transform outcomes for patients living with COPD and severe lower respiratory tract disease.

Accountabilities:

US Medical Strategy & Asset Leadership - Serve as the US medical lead for COPD Biologics, accountable for development and execution of the US Brand Medical Plan across pre and post-approval stages.

Provide strategic medical input to US brand and launch strategy, ensuring alignment of scientific priorities with patient and clinical needs.

Translate complex biology, clinical data, and disease state-insights into actionable US medical strategies.

Pre-Approval Medical Affairs Responsibilities - Lead US medical strategy for late-stage clinical development, including:

US input into Phase 3/3b study design

Endpoint relevance to US clinical practice

Subpopulation and biomarker strategy

Support US regulatory readiness through medical review, scientific positioning, and collaboration with regulatory and global partners.

Develop and implement pre-approval external scientific engagement strategy consistent with regulations, including:

Scientific exchange on disease biology and unmet need

Advisory boards focused on clinical trial interpretation and future treatment paradigms

Contribute to launch readiness planning, including:

Medical education strategy

Scientific platform development

Medical training for Field Medical teams

Partner with evidence, payer, and outcomes teams to define early value evidence strategy relevant to the US healthcare environment.

Post-Approval Medical Affairs Responsibilities - Lead ongoing post-approval medical strategy to support appropriate scientific exchange and optimize patient care.

Lead all aspects of Phase 4 and lifecycle management strategy, including real-world-evidence (RWE) and effectiveness studies relevant to US clinicians and payers.

Provide medical leadership for:

US publication strategy and congress planning

Medical review of promotional and non-promotional materials

Scientific response strategy and data dissemination

Serve as a medical spokesperson for the US brand as appropriate, supporting external scientific discussions and media inquiries.

Maintain accountability for the evolving US product scientific narrative, incorporating new data, guidelines, and real-world insights.

External Engagement & Scientific Exchange (US Focused) - Design and implement a comprehensive US external engagement plan, including:

Key Opinion Leaders (KOLs)

Academic institutions

Integrated delivery networks and hospital systems

Professional societies

Lead planning and participation in national and regional US medical advisory boards.

Ensure high-quality, compliant scientific exchange that advances understanding of COPD pathophysiology.

Evidence Generation & Medical Governance - Collaborate with medical evidence and payer teams to design and implement:

Clinical effectiveness studies

RWE and health outcomes research

Provide medical review and governance for Externally Sponsored Research (ESR) proposals.

Provide medical input into product safety strategy in collaboration with Patient Safety colleagues.

Ensure compliance with all US regulatory requirements, OPDP standards, PhRMA Code, and AstraZeneca policies.

Internal Collaboration & Capability Building - Provide clinical education and scientific training for:

US Field Medical organization

Cross-functional-partners (commercial, market access, HEOR)

Act as a trusted US medical advisor to internal team members on COPD disease strategy and emerging science.

Maintain strong collaboration with global medical and clinical teams, ensuring seamless alignment while representing US medical needs.

Minimum Requirements - Doctoral degree (MD, PhD, MBBS or PharmD) or equivalent education

3+ years of demonstrated experience or strong expertise in Pulmonary Medicine, respiratory pharmacology, or immune-mediated-disease.

Experience in late-phase clinical development and/or post-approval medical affairs.

Well-developed comprehension of the US regulatory environment, including FDA and OPDP.

Excellent scientific communication, presentation, and customer engagement skills.

Ability to travel 20-25% on average within the US and occasionally internationally.

Preferred Requirements - Board certification or eligibility in Pulmonary or Internal Medicine.

Strong biologics and new product launch experience

Prior US pharmaceutical medical affairs experience, preferably in respiratory or biologics.

Experience supporting first-in-class, disease-modifying, or specialty launches.

Strong understanding of the US payer and provider landscape.

Demonstrated success in cross-functional-leadership and launch execution.

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Constructor is the next-generation platform for search and discovery in ecommerce, built to explicitly optimize for metrics like revenue, conversion rate, and profit.

Our search engine is entirely invented in-house utilizing transformers and generative LLMs, and we use its core and personalization capabilities to power everything from search itself to recommendations to shopping agents.

Engineering is by far our largest department, and we’ve built our proprietary engine to be the best on the market, having never lost an A/B test to a competitive technology.

We’re a team who love solving problems and want to make our customers’ and coworkers’ lives better.

About You

You're a product designer who owns problems, not screens. You're comfortable with ambiguity, can partner with PMs to shape direction, and know how to translate research insights into production-ready interfaces, working closely with engineers.

The Team

Our AI Agent Tools team is building a new category of e-commerce experience: intelligent agents that guide shoppers, learn from merchandiser expertise, and drive real business outcomes.

Responsibilities

You'll be designing the future of product discovery: the moment a shopper goes from intent to purchase, reimagined through AI.

• You'll define what agentic shopping looks like , Not just chatbots bolted onto search, but genuinely new interaction patterns where AI understands what a shopper wants and helps them get there.

• You'll shape how merchandisers control it , You will collaborate with Agent Orchestrators,professionals blending data analysis, design, and shopper psychology,to design the dashboard tools that allow them to configure, train, and optimize new shopping journeys without engineering support.

• You'll prove it works in the real world , From running UI experiments on live retailer sites to validating new shopping experiences with actual shopper data, your designs ship and get measured.

What You'll Own

• Research & validation , Conducting shopper research and running experiments alongside product and data teams to validate hypotheses with real input.

• Interaction design for agentic experiences , Mapping novel user flows where AI/LLMs drive the shopping journey, for both shoppers and the merchandisers who orchestrate them.

• Visual strategy , Defining a bold design direction that represents what product discovery looks like in 2027.

• High-fidelity delivery , Producing final mockups and assets across key surfaces: homepage, search, PDP, filtering, guided shopping, and agent configuration.

• UX patterns , Ensuring designs scale within Constructor’s evolving design system and component library.

Benefits

• Work with smart and empathetic people who will help you grow and make a meaningful impact.

• Regular team offsite events to connect and collaborate.

• Fully remote team - choose where you live.

• Unlimited vacation time - we strongly encourage all of our employees take at least 3 weeks per year.

• Work from home stipend! We want you to have the resources you need to set up your home office.

• Apple laptops provided for new employees.

• Training and development budget for every employee, refreshed each year.

• Maternity & Paternity leave for qualified employees.

• Stock options - offered in addition to the base salary

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You'll translate infrastructure and product capabilities into commercial propositions, partnering with Sales and Marketing to ensure international enterprise and government customers understand what Anthropic can deliver, and when. You'll serve as the internal subject matter expert on international readiness requirements, advising on deals, partnerships, and policy positions as they arise.

You'll build scalable processes for capturing, triaging, and acting on international product feedback so it doesn’t get lost in HQ product cycles. You'll serve as the GTM strategist for Anthropic’s mission-oriented international programs, including our approach to responsible AI deployment in democratic allied nations and our strategy for expanding access and affordability in Global South markets.

You'll partner with Policy, Beneficial Deployments, and Global Affairs to ensure mission programs have a viable commercial and infrastructure foundation, not just a policy framework. You'll track and synthesise the competitive landscape for sovereign AI and national AI programs, surfacing implications for Anthropic’s positioning and commercial strategy.

Responsibilities

• Contribute to Anthropic’s international compute strategy
• Develop a framework for evaluating and sequencing data residency and sovereign deployment requests
• Identify and document international customer requirements for product localization
• Translate infrastructure and product capabilities into commercial propositions
• Serve as the internal subject matter expert on international readiness requirements
• Build scalable processes for capturing, triaging, and acting on international product feedback
• Serve as the GTM strategist for Anthropic’s mission-oriented international programs
• Partner with Policy, Beneficial Deployments, and Global Affairs to ensure mission programs have a viable commercial and infrastructure foundation

Requirements

• 5–7 years in product, technical GTM, solutions engineering, or strategy roles with meaningful international scope
• Strong working knowledge of cloud infrastructure, data residency frameworks, and enterprise compliance requirements
• Experience working with or selling to government customers or regulated enterprises
• Ability to synthesise complex technical, regulatory, and geopolitical constraints into clear commercial and strategic recommendations
• Comfortable building internal processes from scratch
• High autonomy and strong written communication
• Direct experience with sovereign cloud programs, regulated data environments, or government AI initiatives is a plus
• Familiarity with EU AI Act, India DPDP Act, or similar regulatory frameworks shaping enterprise AI deployment internationally is a plus
• Experience at a hyperscaler, cloud provider, or enterprise SaaS company navigating international infrastructure decisions is a plus
• An interest in the intersection of AI, democratic governance, and responsible technology deployment is a plus
• Annual salary: £120,000-£170,000 GBP

$190,000-$270,000 USD

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