Rezo Therapeutics is a biopharma company developing a disease-agnostic, fully-integrated, network biology platform to redefine the understanding of human disease and ability to treat it. Located in San Francisco's vibrant Mission Bay neighborhood, Rezo is in close proximity to UCSF, numerous urban amenities, and outdoor recreational opportunities.

The Opportunity

We are hiring a Senior Scientist, Discovery Biology to join Rezo's Biology Team. In this role, you will collaborate with an interdisciplinary group combining genetics, proteomics, structural biology, and AI to tackle challenging biological questions and develop transformative therapies.

Key Responsibilities:

• Develop and optimize molecular and cellular assays to study protein function in 2D/3D tumor models.
• Design and execute CRISPR-based genetic studies to evaluate target function and therapeutic potential.
• Develop and conduct cell-based functional assays to profile small molecule drugs and inform structure-activity relationships (SAR).
• Analyze experimental data, interpret findings, and prepare reports for internal discussions, regulatory filings.
• Collaborate across interdisciplinary teams and effectively communicate scientific results.
• Manage multiple projects efficiently in a dynamic and fast-paced setting.

Qualifications:

• PhD in cancer biology, or a related field with relevant postdoctoral or industry experience.
• Candidates with a Master’s or Bachelor’s degree with 10-12+ years of expertise, including CRISPR technologies and cancer research, are also encouraged to apply.
• Strong hands-on experience with 2D/3D tumor models and molecular biology techniques.
• Proficiency in genetic manipulation of cancer cells, including CRISPR/Cas9, RNAi, and other genome-editing tools.
• In-depth knowledge of the molecular and cellular mechanisms driving oncogenesis.
• Skilled in performing immunoblotting, proliferation/apoptosis assays, and phenotypic screening assays.
• Proven ability to work independently while fostering collaboration in a team environment.
• Excellent organizational, communication, and interpersonal skills.

Additional Information

Compensation at Rezo

The expected starting salary range for this position based in San Francisco, California for Sr. Scientist is $135,000-$190,000. Actual starting salary will be determined based on multiple job-related factors including candidate’s skills, education, and experience, the level at which they are hired, market demand, business needs, and internal parity.

Benefits at Rezo

Medical (HMO or PPO), dental, and vision insurance Discretionary time off policy Company holidays (including summer and winter shutdown) 401(k) retirement savings program Commuter / Mass Transit Benefit Program Healthcare Flexible Spending Account (FSA) Dependent care Flexible Spending Account (FSA) Parental leave Competitive compensation Flexible work schedule

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The role reports to the Supervisor, R&D Labs. This role will be an Onsite role.

Responsibilities: Collaborate with the Research, Development, Automation, Facilities and Supply Chain teams to ensure consistent laboratory support. Assist Research Associates and Scientists in preparing and aliquoting reagents. Perform routine maintenance on a variety of laboratory equipment. Assist with troubleshooting R&D lab equipment issues using established SOPs and WI’s. Operate automated liquid handling platforms to execute automated procedures. Assist with monitoring cold storage temperatures and respond to temperature excursion events. Assist with organizing and maintaining R&D reagent and sample inventory documentation. Act as a role model by demonstrating adherence to all proper safety protocols. Perform Accessioning and processing of patient samples. Support Biosample Management by picking and pulling samples. Contribute to Study Execution by performing Genomics workflows.

Requirements: Bachelor's Degree with 1-2 years of related experience. Strong communication skills and the ability to collaborate across disciplines. Experience in writing or updating documentation such as WI’s, SOPs and maintaining a detailed Lab notebook. Ability to follow SOPs and troubleshoot effectively. Strong understanding of current molecular biology techniques and DNA sequencing. Attention to detail and documentation practices within a repetitive work function.

Nice to Have: Valuable supplementary skills include: Experience handling and preparing blood and tissue samples. Proficiency with automated liquid handling platforms and software. Experience setting up Illumina sequencers. Experience maintaining laboratory equipment. Experience writing or updating documentation such as work instructions and SOPs. Experience working in BSL-2 laboratories and familiarity with 5S organizational practices.

Benefits and Additional Information: The US target range of our hourly rate for new hires is $30.60 - $39.12. You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered.

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The role reports to the Supervisor, R&D Labs. This role will be an Onsite role.

Responsibilities: Collaborate with the Research, Development, Automation, Facilities and Supply Chain teams to ensure consistent laboratory support. Assist Research Associates and Scientists in preparing and aliquoting reagents. Perform routine maintenance on a variety of laboratory equipment. Assist with troubleshooting R&D lab equipment issues using established SOPs and WI’s. Operate automated liquid handling platforms to execute automated procedures. Assist with monitoring cold storage temperatures and respond to temperature excursion events. Assist with organizing and maintaining R&D reagent and sample inventory documentation. Act as a role model by demonstrating adherence to all proper safety protocols. Perform Accessioning and processing of patient samples. Support Biosample Management by picking and pulling samples. Contribute to Study Execution by performing Genomics workflows.

Requirements: Bachelor's Degree with 1-2 years of related experience. Strong communication skills and the ability to collaborate across disciplines. Experience in writing or updating documentation such as WI’s, SOPs and maintaining a detailed Lab notebook. Ability to follow SOPs and troubleshoot effectively. Strong understanding of current molecular biology techniques and DNA sequencing. Attention to detail and documentation practices within a repetitive work function.

Nice to Have: Valuable supplementary skills include: Experience handling and preparing blood and tissue samples. Proficiency with automated liquid handling platforms and software. Experience setting up Illumina sequencers. Experience maintaining laboratory equipment. Experience writing or updating documentation such as work instructions and SOPs. Experience working in BSL-2 laboratories and familiarity with 5S organizational practices.

Benefits and Additional Information: The US target range of our hourly rate for new hires is $30.60 - $39.12. You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered.

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Key Responsibilities:

Perform automated and manual high-throughput processing on the BigHat platform, including DNA preparation, protein expression, and protein characterization. Contribute to the scaling up of BigHat's platform and production-grade data generation. Support BigHat's Platform Reagents & Assay Support (PRAS) function by contributing to in-house reagent manufacturing efforts. Execute experiments to optimize the performance efficiency of BigHat's platform. Keep a detailed record of all experiments using BigHat's documentation tools, and clearly communicate results and challenges. Collaborate on the creation of laboratory standard operating procedures (SOPs) for sample processing. Collaborate closely with BigHat team members to identify, design, and implement critical process and operational improvements to production workflows and laboratory systems. Operate automated liquid handlers and analytical instruments to ensure all lab and platform operations run efficiently.

Skills, Knowledge & Expertise:

BS in Biology or Chemistry, with 1+ year(s) of industry experience Experience in process execution, laboratory method development, optimization, and troubleshooting. Hands-on experience with, or interest in, automated liquid handlers (e.g. Hamilton, OpenTrons, Tecan, Agilent systems). Experience with molecular biology techniques and general lab practices. Efficient time management and ability to work on several projects simultaneously, in a dynamic start-up environment. Strong interpersonal skills and ability to effectively communicate with members of a multidisciplinary team. Excellent record keeping abilities to document experimental work and analytical data. Nice-to-haves include previous experience working with barcoding systems, inventory tracking, and experience with Google Workspace tools (Docs, Sheets, Slides, etc.).

Benefits: The salary estimated for this position is $75,000 - $105,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer. Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived) Dental, and vision coverage through Guardian Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more 401(k) with company match DTO, two weeks of company-wide shutdown, and 12 company holidays Paid parental leave

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