This role will report to the Vice President Clinical Respiratory.

The GCH will be accountable for all clinical scientific aspects of the product/asset, including the benefit/risk of a product and/or asset as well as the scientific strategies for clinical components of the Target Product Profile (TPP), Target Product Claim (TPC), Clinical Development Plan (CDP), Clinical components of regulatory documents and core labelling texts.

Provide clinical and medical expertise input into overall project strategy.

Will have accountability for the clinical deliverables i.e. clinical studies, clinical components of regulatory submissions etc to time.

Serve as the single point of contact for TA-Heads and R&D leaders for clinical and scientific components of the product and/or indications.

Essential for the Role:

• An MD, or other equivalent medical degree from an accredited university with specialty training in Respiratory or related area.

• 7 years’ relevant experience within the respiratory space, including late-phase drug development experience.

• Demonstrated deep clinical and research expertise in appropriate disease area

• Significant hands-on late phase clinical drug development experience.

• Developed/delivered multiple complex and large studies (e.g., including but not limited to multinational outcome studies).

• Scientific credibility internally and externally.

• Demonstrated success in influencing functions outside of clinical and across geographies.

• Experience of benefit/risk assessment and creating patient risk management plans.

• Experience of global regulatory submissions and interacting with major regulatory agencies.

• Demonstrated ability to successfully lead, coach, and mentor other physicians/scientists.

• Proven teamwork and collaboration skills in a global setting.

• Credible in scientific and commercial environments.

• Fit for purpose business acumen, and insight into payer and reimbursement hurdles globally

• Line management experience.

Desirable for the role:

• Global external awareness within the therapeutic area.

• Global regulatory awareness.

• Ability to travel nationally and internationally.

• Experience in several organizations and geographic locations

• Experience of working with Market Companies to deliver studies/projects.

• Experience of clinical/commercial interface.

At AstraZeneca, we seize opportunities for change and make them happen, delivering life-changing medicines through entrepreneurship and innovation.

Join us in our unique and ambitious world, where we work from the office three days a week, balancing flexibility and collaboration.

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees.

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Provide indication and asset leadership by translating therapy area priorities into clear indication strategies, setting direction and making evidence-based trade-offs across the cluster to benefit global medical objectives, acting as final escalation point for sophisticated benefit-risk and reputational decisions.

Drive global medical strategy through cross-functional engagement by ensuring Sr GMAL/GMALs consistently lead key forums with markets, and by standardising operating cadences that align Development, Regulatory, Pharmacovigilance, Access, and non-promotional Commercial teams around the medical plan.

Lead all aspects of evidence generation governance by mentoring and approving indication evidence plans that address the most critical gaps, crafting strategy and develop of medical evidence (Phase IV, pragmatic studies, registries, RWE, IIS) and guiding operational support to deliver on time and on budget.

Share accountability for publications by partnering with Publications on cluster publication strategies, endorsing prioritisation, authorship plans and timelines, securing GPT/GPL endorsement, and ensuring scientific integrity and compliance with GPP/ICMJE.

Lead the cross-indication scientific narrative by ensuring Sr GMAL/GMALs lead coherent narratives and confidence-building strategies that are consistent across channels, geographies, and lifecycle stages.

Define medical education priorities at cluster level and provide subject-matter guidance so medical training and communications teams can design, develop, and deliver education aligned to the scientific platform.

Direct external engagement and partnerships strategy across indications, being responsible for execution with KEEs, societies, and appropriate partners in alignment with MESO on partnership frameworks and governance.

Lead congress strategy by defining the cross-indication congress plan, guiding symposia strategy, abstracts, booth scientific narratives, compliant engagements, and ensuring magnificent execution and robust post-congress insight collection.

Enable regions and integrate insights by sponsoring toolkits, core content, and training, establishing closed-loop insight systems so market feedback rapidly updates strategy, studies, and content.

Drive operational excellence by leading the cluster budget and vendor ecosystem, setting standards for medical planning, dashboards, risk and issue management, and MLR processes, while optimising FTE allocation across Sr GMAL/GMAL teams based on launch timing and complexity.

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