The role reports to Manager, Scientific Operations. This role will be an onsite role based in our Brisbane, California headquarters.

Responsibilities:

• Perform routine lab work including pre-analytical sample processing, plasma isolation, and downstream genomics and proteomics assay processing.
• Operate liquid handler instruments to carry out experiments.
• Troubleshoot instrument and sample processing errors as needed; escalate and report issues through appropriate channels as needed.
• Identify and implement process improvements across the lab by thinking critically about the execution of all experiments.
• Verify all aspects of incoming specimens and assess acceptability for analytical testing.
• Maintain documentation for executed experiments.
• Perform equipment maintenance according to the laboratory's standard operating procedures for the following but not limited to: Hamiltons, Biosafety Cabinets, centrifuges, freezers, refrigerators, and pipettes, as needed.
• Assist with training of new laboratory personnel and training of new procedures with existing personnel.
• Document all corrective actions taken when test systems deviate from the laboratory's established performance specifications.
• Report all concerns of test quality and/or safety to the Supervisor or Safety Officer.
• Perform other miscellaneous laboratory duties as assigned and assist others as time allows.

Requirements:

• Bachelor's degree or Master's degree in molecular biology, biochemistry, genetics, chemical biology, or a related field.
• 2+ years relevant industry experience in a laboratory setting.
• Experience working with 96 or 384 well plate format assays.
• Proven track record of following SOPs, work instructions or experimental designs to completion.
• Strong organizational skills and attention to detail.
• Ability to work, execute, and troubleshoot protocols independently.

Nice to Have:

• Working understanding of GLP.
• Experience with NGS library preparation and/or sequencing.
• Experience with ELISA, Luminex, or other immunoassays.
• Familiarity with Liquid Handlers - Bravo, Hamilton, etc.

Benefits and Additional Information:

The US target range of our hourly rate for new hires is $37.68 - $46.69. You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company's sole discretion and may vary based on several factors, including but not limited to, location, skill level, years and depth of relevant experience, and education.

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Key Responsibilities:

Perform automated and manual high-throughput processing on the BigHat platform, including DNA preparation, protein expression, and protein characterization. Contribute to the scaling up of BigHat's platform and production-grade data generation. Support BigHat's Platform Reagents & Assay Support (PRAS) function by contributing to in-house reagent manufacturing efforts. Execute experiments to optimize the performance efficiency of BigHat's platform. Keep a detailed record of all experiments using BigHat's documentation tools, and clearly communicate results and challenges. Collaborate on the creation of laboratory standard operating procedures (SOPs) for sample processing. Collaborate closely with BigHat team members to identify, design, and implement critical process and operational improvements to production workflows and laboratory systems. Operate automated liquid handlers and analytical instruments to ensure all lab and platform operations run efficiently.

Skills, Knowledge & Expertise:

BS in Biology or Chemistry, with 1+ year(s) of industry experience Experience in process execution, laboratory method development, optimization, and troubleshooting. Hands-on experience with, or interest in, automated liquid handlers (e.g. Hamilton, OpenTrons, Tecan, Agilent systems). Experience with molecular biology techniques and general lab practices. Efficient time management and ability to work on several projects simultaneously, in a dynamic start-up environment. Strong interpersonal skills and ability to effectively communicate with members of a multidisciplinary team. Excellent record keeping abilities to document experimental work and analytical data. Nice-to-haves include previous experience working with barcoding systems, inventory tracking, and experience with Google Workspace tools (Docs, Sheets, Slides, etc.).

Benefits: The salary estimated for this position is $75,000 - $105,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer. Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived) Dental, and vision coverage through Guardian Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more 401(k) with company match DTO, two weeks of company-wide shutdown, and 12 company holidays Paid parental leave

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