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YubHub-native raw fields carry `x-` prefix.","jobs":[{"@context":"https://schema.org","@type":"JobPosting","identifier":{"@type":"PropertyValue","name":"YubHub","value":"job_4ee3aa8d-ab3"},"title":"Senior Scientist, Viral Vector Process Development, Upstream","description":"<p>We are looking for a highly motivated and experienced Senior Scientist, Viral Vector Process Development (Upstream) to join our team. As a key member of our Cell Therapy modalities portfolio, you will play a critical role in building and leading a high-performing team that accelerates AstraZeneca&#39;s emerging Cell Therapy modalities portfolio.</p>\n<p>Your primary focus will be on designing, executing, and optimizing upstream Lentiviral Vector (LVV) processes with a primary focus on suspension bioreactor platforms at clinical and commercial scales. You will contribute hands-on to experimental design, process characterization, and scale-up/tech transfer activities from research through IND enabling, partnering closely with Research, Analytical Development, CMC, Regulatory, Manufacturing, Quality, and external CDMOs.</p>\n<p>Key Responsibilities:</p>\n<ul>\n<li>Plan and perform experiments to develop and optimize LVV upstream processes for suspension cell culture (transient or stable producer cell systems), targeting improvements in titer, quality, robustness, and cost.</li>\n</ul>\n<ul>\n<li>Execute unit operations across seed, production, and harvest interfaces; support scale-up strategies from bench to pilot and clinical scales; develop and use scale-down models for characterization and comparability.</li>\n</ul>\n<ul>\n<li>Design DOE studies, identify CPPs/CMAs, analyze data, and propose control strategies; document results in protocols and reports; maintain fit for-purpose knowledge records.</li>\n</ul>\n<ul>\n<li>Contribute to definition of design space, in-process controls, and operating ranges; trend process performance and drive troubleshooting, root cause analysis, and corrective actions.</li>\n</ul>\n<ul>\n<li>Prepare technical transfer packages and support transfers to internal GMP sites and CDMOs; align process documentation with cGMP principles for late-stage readiness.</li>\n</ul>\n<ul>\n<li>Work closely with Analytical Development on assay readiness and in process testing; partner with Manufacturing, Supply, and Quality to ensure operational feasibility and compliance.</li>\n</ul>\n<ul>\n<li>Apply Lean practices and digital tools for scheduling, data integrity, and reproducibility; track KPIs (titer, infectivity, impurity profiles, cycle time, right first time) and recommend improvements.</li>\n</ul>\n<p>Qualifications:</p>\n<ul>\n<li>Education: Ph.D. in Chemical Engineering, Biochemical Engineering, Biotechnology, or related field with 1+ years of industry experience; OR M.S. with 4+ years; OR B.S. with 5+ years of hands-on industry experience.</li>\n</ul>\n<ul>\n<li>Experience: Hand-on experience developing suspension-based LVV upstream processes; familiarity with clinical/commercial scale considerations, process characterization, and technology transfer.</li>\n</ul>\n<ul>\n<li>Technical Skills: Proficiency in suspension cell culture, transfection/infection strategies, media/feed optimization, single-use rocking-platform and stirred-tank bioreactors, and upstream-harvest interfaces; working knowledge of statistical DOE and data analytics tools.</li>\n</ul>\n<ul>\n<li>GMP Readiness: Experience supporting cGMP interfaces (documentation, change control, sampling plans) and contributing to CMC sections or technical responses is a plus.</li>\n</ul>\n<ul>\n<li>Communication &amp; Teamwork: Strong written and verbal communication skills; ability to work effectively in cross-functional, matrixed teams; demonstrated problemsolving and troubleshooting capability.</li>\n</ul>\n<ul>\n<li>Tools &amp; Automation: Experience with single-use systems, process automation/PAT, and digital lab systems (ELN/LIMS) preferred.</li>\n</ul>\n<p>Preferred Qualifications:</p>\n<ul>\n<li>Demonstrated success scaling suspension LVV processes to pilot/clinical scales and sustaining performance via monitoring and continuous improvement.</li>\n</ul>\n<ul>\n<li>Experience linking upstream parameters to analytical outcomes (titer, infectivity/potency, residuals/impurities) to guide process decisions.</li>\n</ul>\n<ul>\n<li>Contributions to regulatory filings (data tables, process descriptions) and participation in tech transfer to CDMOs or internal GMP sites.</li>\n</ul>\n<ul>\n<li>Experience implementing Lean/continuous improvement and robust documentation/knowledge management in PD labs.</li>\n</ul>\n<p style=\"margin-top:24px;font-size:13px;color:#666;\">XML job scraping automation by <a href=\"https://yubhub.co\">YubHub</a></p>","url":"https://yubhub.co/jobs/job_4ee3aa8d-ab3","directApply":true,"hiringOrganization":{"@type":"Organization","name":"Viral Vector and New Modalities Cell Therapy Operations","sameAs":"https://astrazeneca.eightfold.ai","logo":"https://logos.yubhub.co/astrazeneca.eightfold.ai.png"},"x-apply-url":"https://astrazeneca.eightfold.ai/careers/job/563877689868523","x-work-arrangement":"onsite","x-experience-level":"senior","x-job-type":"full-time","x-salary-range":"$108,473.60 - 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Hiring and training talent who can manage material flow per Anduril guidelines. Developing processes that increase the efficiency and effectiveness of Anduril materials management. Implementing necessary systems that match Anduril Federal policies on management of government property and inventory management. Implementing end-to-end material management measures, including FIFO adherence, material variances, cycle time optimisation, scrap/obsolescence management, cycle/physical counting, and audits, etc., to ensure inventory accuracy and to mitigate stockouts or overstocking. Collaborating with cross-functional teams, including procurement, production, manufacturing engineering, logistics, and quality, to aid in accurate demand forecasting, procurement planning, and timely delivery of materials. Collaborating with production planning and manufacturing teams to align material availability with production schedules, minimise disruptions, and meet customer demand on time. 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Ensure compliance with regulatory requirements, safety standards, and quality control protocols in all material management activities. 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