Your leadership will be pivotal in ensuring our facilities support the delivery of life-changing medicines worldwide. Collaborate with cross-functional teams and stakeholders to set visionary strategies for growth and challenge the status quo with data-driven insights.

This is your chance to build resilient operations that empower colleagues and elevate performance. If you thrive in dynamic environments and are eager to make a lasting impact, this role is your platform to lead and innovate.

Accountabilities

• Ignite transformation and lead a multi-level, multi-disciplined organization, cultivating a dynamic culture where progressive ideas and standards are celebrated.
• Set the vision and strategic direction for facilities infrastructure, maintenance, and SHE programs, empowering your team to deliver breakthrough solutions that shape both short-term achievements and long-term business success.
• Take ownership for the entire site infrastructure and facilities program,including grounds, building exteriors/interiors, asset and systems reliability, regulatory adherence, documentation, calibration, resource stewardship, space management, and the seamless delivery of services via in-house experts and strategic contractors.
• Champion digital innovation, maximising modern technologies, smart analytics, conditioned based monitoring, smart metering, predictive maintenance tools/system to enhance facility performance, streamline operations, and achieve new levels of safety and efficiency.
• Direct the activities of Site Facilities Management departments,including Maintenance, Site Services, Housekeeping, and Security,ensuring exceptional asset reliability, regulatory compliance, and an outstanding service experience for all site partners.
• Spearhead innovative sustainability initiatives and outcomes, integrating environmentally responsible solutions that support our business, community, and global commitments.
• Foster effective coordination across site functions, driving proactive annual capital planning and execution closely aligned with the facility master plan, asset lifecycle strategies, and fiscal discipline.
• Promote a culture of integrity and compliance, ensuring all programs, managers, staff, and external providers closely adhere to AstraZeneca’s policies, international standards, and all relevant Safety, Health & Environmental regulations.
• Build trusted relationships with local, state, and federal agencies, taking charge of licensing, inspections, and all regulatory obligations necessary for uninterrupted site operations.
• Pursue and achieve ambitious critical metric targets across Customer Service, Compliance, Cost, Safety, Quality, Productivity, and Organizational Capability, leveraging data-driven insights for continual site improvement.
• Coach and mentor the Facilities, Maintenance, and SHE teams,unlocking professional growth, supporting career development, encouraging continuous learning, and driving high-performance outcomes.
• Conduct activities and interactions consistent with What we value and in compliance with the Code of Conduct and supporting Policies and Standards relevant to your role.

Essential Skills/Experience

• Bachelors: Engineering – Mechanical, Chemical or Biochemical or relevant experience in lieu of a degree.
• 10 years experience in a GMP, FDA regulated environment.
• Effective ability to coach, empower, and develop team.
• Experience with driving transformative change throughout an organization or function.
• Demonstrated ability in strategy development for facility programs, maintenance programs, and SHE programs.
• Ability to effectively build relationships with as well as manage internal and external stakeholders.
• Good understanding of Safety, Health and Environment programs.
• Training or experience in formulation, packaging, aseptic operations, warehouse, and related facilities.
• Experience working in a LEAN manufacturing environment.
• Controls / automation experience.
• Multiple Site or cross functional experience.
• Advanced knowledge of compliance requirements.

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This role is ideally suited for a physician or pharmacist with deep expertise in pulmonary medicine and experience across late-stage development, launch readiness, and post-approval medical excellence. The Medical Director ensures US medical strategy is aligned with global direction while remaining responsive to the healthcare and clinical landscape within the United States.

At AstraZeneca, teams work across global boundaries to make an impact and find answers to complex challenges. This role sits at the heart of that mission, combining scientific depth with strategic leadership to advance care in chronic respiratory disease.

This position completes the medical strategy and carries out the execution for a novel Interleukin-33 targeting monoclonal antibody, crafting both product and disease area direction across the full lifecycle.

Reporting directly to the US Medical Head, COPD Biologics, this leader will guide a high-performing team, drive launches, and influence how evidence, access, and clinical practice come together to transform outcomes for patients living with COPD and severe lower respiratory tract disease.

Accountabilities:

US Medical Strategy & Asset Leadership - Serve as the US medical lead for COPD Biologics, accountable for development and execution of the US Brand Medical Plan across pre and post-approval stages.

Provide strategic medical input to US brand and launch strategy, ensuring alignment of scientific priorities with patient and clinical needs.

Translate complex biology, clinical data, and disease state-insights into actionable US medical strategies.

Pre-Approval Medical Affairs Responsibilities - Lead US medical strategy for late-stage clinical development, including:

US input into Phase 3/3b study design

Endpoint relevance to US clinical practice

Subpopulation and biomarker strategy

Support US regulatory readiness through medical review, scientific positioning, and collaboration with regulatory and global partners.

Develop and implement pre-approval external scientific engagement strategy consistent with regulations, including:

Scientific exchange on disease biology and unmet need

Advisory boards focused on clinical trial interpretation and future treatment paradigms

Contribute to launch readiness planning, including:

Medical education strategy

Scientific platform development

Medical training for Field Medical teams

Partner with evidence, payer, and outcomes teams to define early value evidence strategy relevant to the US healthcare environment.

Post-Approval Medical Affairs Responsibilities - Lead ongoing post-approval medical strategy to support appropriate scientific exchange and optimize patient care.

Lead all aspects of Phase 4 and lifecycle management strategy, including real-world-evidence (RWE) and effectiveness studies relevant to US clinicians and payers.

Provide medical leadership for:

US publication strategy and congress planning

Medical review of promotional and non-promotional materials

Scientific response strategy and data dissemination

Serve as a medical spokesperson for the US brand as appropriate, supporting external scientific discussions and media inquiries.

Maintain accountability for the evolving US product scientific narrative, incorporating new data, guidelines, and real-world insights.

External Engagement & Scientific Exchange (US Focused) - Design and implement a comprehensive US external engagement plan, including:

Key Opinion Leaders (KOLs)

Academic institutions

Integrated delivery networks and hospital systems

Professional societies

Lead planning and participation in national and regional US medical advisory boards.

Ensure high-quality, compliant scientific exchange that advances understanding of COPD pathophysiology.

Evidence Generation & Medical Governance - Collaborate with medical evidence and payer teams to design and implement:

Clinical effectiveness studies

RWE and health outcomes research

Provide medical review and governance for Externally Sponsored Research (ESR) proposals.

Provide medical input into product safety strategy in collaboration with Patient Safety colleagues.

Ensure compliance with all US regulatory requirements, OPDP standards, PhRMA Code, and AstraZeneca policies.

Internal Collaboration & Capability Building - Provide clinical education and scientific training for:

US Field Medical organization

Cross-functional-partners (commercial, market access, HEOR)

Act as a trusted US medical advisor to internal team members on COPD disease strategy and emerging science.

Maintain strong collaboration with global medical and clinical teams, ensuring seamless alignment while representing US medical needs.

Minimum Requirements - Doctoral degree (MD, PhD, MBBS or PharmD) or equivalent education

3+ years of demonstrated experience or strong expertise in Pulmonary Medicine, respiratory pharmacology, or immune-mediated-disease.

Experience in late-phase clinical development and/or post-approval medical affairs.

Well-developed comprehension of the US regulatory environment, including FDA and OPDP.

Excellent scientific communication, presentation, and customer engagement skills.

Ability to travel 20-25% on average within the US and occasionally internationally.

Preferred Requirements - Board certification or eligibility in Pulmonary or Internal Medicine.

Strong biologics and new product launch experience

Prior US pharmaceutical medical affairs experience, preferably in respiratory or biologics.

Experience supporting first-in-class, disease-modifying, or specialty launches.

Strong understanding of the US payer and provider landscape.

Demonstrated success in cross-functional-leadership and launch execution.

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Your primary responsibilities will include:

• Responsible for clinical manufacturing novel cell therapy drug substance within the Cell Therapy Module, CT-MOD.
• Collaborates closely with biological development (BD) and Manufacturing Science and Technology (MSAT) for new product introductions and ensures platform alignment.
• Works with a single-cell line from expansion, through differentiation and fill/finish process to manufacture a unique product using single-use technology.
• Manufactures products in various phases of product life cycles from clinical through launch.
• Responsible for all aspects of clinical manufacturing in the following areas: Solution Preparation, Cell Expansion, Cell Culture, and Final Fill and freezing.

In addition, you will:

• Ensure all activities are performed to schedule.
• Clearly understand, communicate, and manage differences in terms of documentation, sample handling, automation, cGMPs, etc. for different phases of the product life cycle.
• Author, redline, and review-controlled documents for various equipment/processes.
• Monitor and control processes using data trending and/or statistical process control.
• Work cross-functionally to ensure process is controlled and issues are escalated and investigated.
• Raise and support investigation of deviations.
• Partner cross-functionally to determine product impact and root cause.
• Implement and execute manufacturing tasks in alignment with effective corrective actions to prevent re-occurrence.
• Participate in regulatory and internal audits.
• Support commissioning and qualification of equipment.
• Participate in safety investigations for CT-MOD and always promote safe behaviors.
• Partner cross-functionally to identify and implement corrective actions.

If you have experience in pharmaceutical operations, preferably biotech or an equivalent combination of education and experience, and possess a strong understanding of FDA, EMA, etc., and cGMP requirements for pharmaceutical manufacturing, we encourage you to apply for this exciting opportunity.

We offer a competitive salary range of $64,000.00 – $97,000.00, additional compensation may include a bonus or commission (if relevant), and a comprehensive benefits package, including health care, vision, dental, retirement, PTO, sick leave, etc.

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• Zone A$251K – $335K • Offers Equity

The base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. If the role is non-exempt, overtime pay will be provided consistent with applicable laws. In addition to the salary range listed above, total compensation also includes generous equity, performance-related bonus(es) for eligible employees, and the following benefits.

• Medical, dental, and vision insurance for you and your family, with employer contributions to Health Savings Accounts

• Pre-tax accounts for Health FSA, Dependent Care FSA, and commuter expenses (parking and transit)

• 401(k) retirement plan with employer match

• Paid parental leave (up to 24 weeks for birth parents and 20 weeks for non-birthing parents), plus paid medical and caregiver leave (up to 8 weeks)

• Paid time off: flexible PTO for exempt employees and up to 15 days annually for non-exempt employees

• 13+ paid company holidays, and multiple paid coordinated company office closures throughout the year for focus and recharge, plus paid sick or safe time (1 hour per 30 hours worked, or more, as required by applicable state or local law)

• Mental health and wellness support

• Employer-paid basic life and disability coverage

• Annual learning and development stipend to fuel your professional growth

• Daily meals in our offices, and meal delivery credits as eligible

• Relocation support for eligible employees

• Additional taxable fringe benefits, such as charitable donation matching and wellness stipends, may also be provided.

About the Team

The AI Deployment Engineering team works at the intersection of cutting-edge AI research and real-world application. We partner directly with OpenAI’s most strategic customers to design, implement, and scale production deployments of generative AI systems. Our work ensures that organizations can safely and effectively integrate AI into critical workflows.

Within this team, the Health & Life Sciences (HLS) segment focuses on enabling pharmaceutical manufacturers, biotechnology companies, medical device organizations, contract research organizations (CROs), and health systems to adopt AI responsibly in regulated environments. We work across clinical, scientific, regulatory, and operational functions to unlock meaningful impact while maintaining the highest standards of safety, privacy, and compliance.

About the Role

We are seeking a Manager, AI Deployment Engineering to lead our Healthcare & Life Sciences deployment efforts. In this role, you will build and mentor a high-performing team of deployment engineers dedicated to helping HLS organizations move from experimentation to production with OpenAI technologies.

You will operate at both strategic and technical levels , partnering with executive stakeholders, technical leaders, and cross-functional internal teams to deliver secure, compliant, and high-impact AI deployments. This role requires a strong technical foundation, people leadership experience, and a deep appreciation for the complexity of regulated healthcare and life sciences environments.

This role is based in San Francisco or Seattle. We use a hybrid work model of 3 days in the office per week.

Responsibilities

• Own the strategy and operating model of the HLS AI Deployment Engineering team, ensuring alignment with company objectives and the evolving needs of our customers.

• Hire, mentor, and develop a high-impact team of AI Deployment Engineers focused on HLS production deployments

• Establish operating mechanisms, delivery standards, and best practices tailored to regulated environments

• Foster a culture of technical excellence, customer empathy, and responsible AI deployment

• Drive Successful Enterprise Deployments and oversee end-to-end implementation of generative AI applications in production across healthcare and life sciences organizations

• Guide customers through complex integration efforts spanning R&D, clinical development, regulatory affairs, medical affairs, and IT

• Develop scalable frameworks for secure, compliant AI adoption in environments governed by HIPAA, GxP, FDA, EMA, and related regulatory standards

• Ensure measurable impact through activation, adoption, and workflow transformation (e.g., drug discovery acceleration, clinical documentation support, regulatory submission drafting)

• Collaborate closely with Sales, Account Directors, Solutions Architects, Product, Security, and Legal teams

• Serve as a trusted technical advisor to executive and senior technical stakeholders at enterprise HLS customers

• Provide structured product feedback informed by real-world deployment challenges and industry requirements

Requirements

• Have 8+ years of experience in technical delivery, solutions engineering, or deployment roles, including people management experience

• Have led enterprise-scale implementations of AI, ML, or platform technologies

• Bring experience in healthcare or life sciences environments, including familiarity with clinical research, drug development, regulatory operations, or health system infrastructure

• Understand compliance frameworks such as HIPAA, GxP, and global regulatory considerations

• Are comfortable engaging with executive stakeholders while maintaining technical depth

• Enjoy operating in ambiguous, fast-moving environments and building structure where it does not yet exist

• Care deeply about responsible AI and its application in high-stakes domains

About OpenAI

OpenAI is an AI research and deployment company dedicated to ensuring that general-purpose artificial intelligence benefits all of humanity. We push the boundaries of the capabilities of AI systems and seek to safely deploy them to the world through our products. AI is an extremely powerful tool that must be created with safety and human needs at its core, and to achieve our mission, we must encompass and value the many different perspectives, voices, and experiences that form the full spectrum of humanity.

We are an equal opportunity employer, and we do not discriminate on the basis of race, religion, color, national origin, sex, sexual orientation, age, veteran status, disability, genetic information, or other applicable legally protected characteristic.

For additional information, please see [OpenAI’s Affirmative Action and Equal Employment Opportunity Policy Statement](https://cdn.openai.com/policies/eeo-policy-statement.pdf).

Background checks for applicants will be administered in accordance with applicable law, and qualified applicants with arrest or conviction records will be considered for employment consistent with those laws, including the San Francisco Fair Chance Ordinance, the Los Angeles County Fair Chance Ordinance for Employers, and the California Fair Chance Act, for US-based candidates. For unincorporated Los Angeles County workers: we reasonably believe that criminal history may have a direct, adverse and negative relationship with the following job duties, potentially resulting in the withdrawal of a conditional offer of employment: protect computer hardware entrusted to you from theft, loss or damage; return all computer hardware in your possession (including the data contained therein) upon termination of employment or end of assignment; and maintain the confidentiality of proprietary, confidential, and non-public information. In addition, job duties require access to sensitive and confidential information, including but not limited to, customer data, financial information, and proprietary technology.

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