Rezo Therapeutics is a biopharma company developing a disease-agnostic, fully-integrated, network biology platform to redefine the understanding of human disease and ability to treat it. Located in San Francisco's vibrant Mission Bay neighborhood, Rezo is in close proximity to UCSF, numerous urban amenities, and outdoor recreational opportunities.

The Opportunity

We are hiring a Senior Scientist, Discovery Biology to join Rezo's Biology Team. In this role, you will collaborate with an interdisciplinary group combining genetics, proteomics, structural biology, and AI to tackle challenging biological questions and develop transformative therapies.

Key Responsibilities:

• Develop and optimize molecular and cellular assays to study protein function in 2D/3D tumor models.
• Design and execute CRISPR-based genetic studies to evaluate target function and therapeutic potential.
• Develop and conduct cell-based functional assays to profile small molecule drugs and inform structure-activity relationships (SAR).
• Analyze experimental data, interpret findings, and prepare reports for internal discussions, regulatory filings.
• Collaborate across interdisciplinary teams and effectively communicate scientific results.
• Manage multiple projects efficiently in a dynamic and fast-paced setting.

Qualifications:

• PhD in cancer biology, or a related field with relevant postdoctoral or industry experience.
• Candidates with a Master’s or Bachelor’s degree with 10-12+ years of expertise, including CRISPR technologies and cancer research, are also encouraged to apply.
• Strong hands-on experience with 2D/3D tumor models and molecular biology techniques.
• Proficiency in genetic manipulation of cancer cells, including CRISPR/Cas9, RNAi, and other genome-editing tools.
• In-depth knowledge of the molecular and cellular mechanisms driving oncogenesis.
• Skilled in performing immunoblotting, proliferation/apoptosis assays, and phenotypic screening assays.
• Proven ability to work independently while fostering collaboration in a team environment.
• Excellent organizational, communication, and interpersonal skills.

Additional Information

Compensation at Rezo

The expected starting salary range for this position based in San Francisco, California for Sr. Scientist is $135,000-$190,000. Actual starting salary will be determined based on multiple job-related factors including candidate’s skills, education, and experience, the level at which they are hired, market demand, business needs, and internal parity.

Benefits at Rezo

Medical (HMO or PPO), dental, and vision insurance Discretionary time off policy Company holidays (including summer and winter shutdown) 401(k) retirement savings program Commuter / Mass Transit Benefit Program Healthcare Flexible Spending Account (FSA) Dependent care Flexible Spending Account (FSA) Parental leave Competitive compensation Flexible work schedule

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