The Executive Director, General Manager Site Head RMC (Rockville Manufacturing Centre) reports into the Head of Cell Therapy Manufacturing within the Cell Therapy Development and Operations (CTDO) organization. This position is responsible for leading all aspects of autologous Cell Therapy manufacturing for a complex stand-alone manufacturing site, meeting customer requirements and enabling the realisation of the company's operations strategy to scale Cell Therapy manufacturing.

Key responsibilities include:

• Leading the RMC Cell Therapy Site for AstraZeneca, the newest cell therapy site
• Ensuring processes at the site are carried out in accordance with AstraZeneca's corporate values, Good Manufacturing Practices, Public Health Codes and applicable standards and laws
• Achieving critical milestones such as PPQ readiness, pre-license inspection, BLA filing support, commercial launch and scaling
• Adopting AI for productivity gains and increasing efficiency in scale
• Acting as a role model for the AZ leadership capabilities and setting the standard by which senior employees on the site motivate and empower staff to deliver outstanding performance and customer service
• Ensuring that the site's products are made available to external customers while adhering to regulations, quality standards, budget and policies
• Setting annual objectives in line with CTDO scorecards, measuring the achievement of those individual targets and taking remedial actions where required
• Championing the design of appropriate methods for improving productivity, quality and SHE standards and overseeing the implementation of these across the site
• Inspiring staff to coach and develop talent to ensure a healthy talent pipeline and succession for senior positions
• Creating an environment in which the working teams can make independent decisions to mitigate any risks to the patient and/or business reputation
• Building and maintaining good reputation and community relations with external stakeholders

Approximate number of people managed: 8-9 direct reports across site supply chain, manufacturing, lean digital, human resources and dotted line MSAT, finance, IT and Quality. In total (all levels): 500-1000.

Preferred Requirements:

• University graduate, with significant experience (10+ years) in the field of Manufacturing, & Supply Chain; People Management and people development
• Proven track record in managing and leading a large, high-performing team with preferred expertise in autologous CAR-T cell therapies or biologics in a clinical and commercial manufacturing environment
• Ability to engage people in change and working with uncertainty and ambiguity

Key skills and competencies:

• Site experience: 10+ years in manufacturing, engineering, facilities, and/or quality site leadership
• Team leadership: Leads a multidisciplinary site leadership team and builds high-performing talent benches
• Regulatory, quality, and SHE governance: Demonstrated oversight ensuring compliance with all applicable standards
• Strategic thinking, influence, and stakeholder management: Translates enterprise strategy into site priorities; influences global and functional stakeholders with credibility and gravitas
• Risk-based decision making: Makes timely, compliant, risk-informed decisions at the site level
• Digital and AI stewardship: Adopts and embeds digital and AI-enabled tools to improve site performance
• Operational execution leadership: Drives OpEx and Lean execution with clear milestones, resource plans, and performance metrics

Join us in our unique and ambitious world, where we balance the expectation of being in the office while respecting individual flexibility. We work five days per week as a site leader/general manager, but that doesn't mean we're not flexible.

Annual base salary for this position ranges from $300,000 to $315,000. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related experience.

XML job scraping automation by YubHub

This role is ideally suited for a physician or pharmacist with deep expertise in pulmonary medicine and experience across late-stage development, launch readiness, and post-approval medical excellence. The Medical Director ensures US medical strategy is aligned with global direction while remaining responsive to the healthcare and clinical landscape within the United States.

At AstraZeneca, teams work across global boundaries to make an impact and find answers to complex challenges. This role sits at the heart of that mission, combining scientific depth with strategic leadership to advance care in chronic respiratory disease.

This position completes the medical strategy and carries out the execution for a novel Interleukin-33 targeting monoclonal antibody, crafting both product and disease area direction across the full lifecycle.

Reporting directly to the US Medical Head, COPD Biologics, this leader will guide a high-performing team, drive launches, and influence how evidence, access, and clinical practice come together to transform outcomes for patients living with COPD and severe lower respiratory tract disease.

Accountabilities:

US Medical Strategy & Asset Leadership - Serve as the US medical lead for COPD Biologics, accountable for development and execution of the US Brand Medical Plan across pre and post-approval stages.

Provide strategic medical input to US brand and launch strategy, ensuring alignment of scientific priorities with patient and clinical needs.

Translate complex biology, clinical data, and disease state-insights into actionable US medical strategies.

Pre-Approval Medical Affairs Responsibilities - Lead US medical strategy for late-stage clinical development, including:

US input into Phase 3/3b study design

Endpoint relevance to US clinical practice

Subpopulation and biomarker strategy

Support US regulatory readiness through medical review, scientific positioning, and collaboration with regulatory and global partners.

Develop and implement pre-approval external scientific engagement strategy consistent with regulations, including:

Scientific exchange on disease biology and unmet need

Advisory boards focused on clinical trial interpretation and future treatment paradigms

Contribute to launch readiness planning, including:

Medical education strategy

Scientific platform development

Medical training for Field Medical teams

Partner with evidence, payer, and outcomes teams to define early value evidence strategy relevant to the US healthcare environment.

Post-Approval Medical Affairs Responsibilities - Lead ongoing post-approval medical strategy to support appropriate scientific exchange and optimize patient care.

Lead all aspects of Phase 4 and lifecycle management strategy, including real-world-evidence (RWE) and effectiveness studies relevant to US clinicians and payers.

Provide medical leadership for:

US publication strategy and congress planning

Medical review of promotional and non-promotional materials

Scientific response strategy and data dissemination

Serve as a medical spokesperson for the US brand as appropriate, supporting external scientific discussions and media inquiries.

Maintain accountability for the evolving US product scientific narrative, incorporating new data, guidelines, and real-world insights.

External Engagement & Scientific Exchange (US Focused) - Design and implement a comprehensive US external engagement plan, including:

Key Opinion Leaders (KOLs)

Academic institutions

Integrated delivery networks and hospital systems

Professional societies

Lead planning and participation in national and regional US medical advisory boards.

Ensure high-quality, compliant scientific exchange that advances understanding of COPD pathophysiology.

Evidence Generation & Medical Governance - Collaborate with medical evidence and payer teams to design and implement:

Clinical effectiveness studies

RWE and health outcomes research

Provide medical review and governance for Externally Sponsored Research (ESR) proposals.

Provide medical input into product safety strategy in collaboration with Patient Safety colleagues.

Ensure compliance with all US regulatory requirements, OPDP standards, PhRMA Code, and AstraZeneca policies.

Internal Collaboration & Capability Building - Provide clinical education and scientific training for:

US Field Medical organization

Cross-functional-partners (commercial, market access, HEOR)

Act as a trusted US medical advisor to internal team members on COPD disease strategy and emerging science.

Maintain strong collaboration with global medical and clinical teams, ensuring seamless alignment while representing US medical needs.

Minimum Requirements - Doctoral degree (MD, PhD, MBBS or PharmD) or equivalent education

3+ years of demonstrated experience or strong expertise in Pulmonary Medicine, respiratory pharmacology, or immune-mediated-disease.

Experience in late-phase clinical development and/or post-approval medical affairs.

Well-developed comprehension of the US regulatory environment, including FDA and OPDP.

Excellent scientific communication, presentation, and customer engagement skills.

Ability to travel 20-25% on average within the US and occasionally internationally.

Preferred Requirements - Board certification or eligibility in Pulmonary or Internal Medicine.

Strong biologics and new product launch experience

Prior US pharmaceutical medical affairs experience, preferably in respiratory or biologics.

Experience supporting first-in-class, disease-modifying, or specialty launches.

Strong understanding of the US payer and provider landscape.

Demonstrated success in cross-functional-leadership and launch execution.

XML job scraping automation by YubHub

Your mission will be to embody our vision of an antedisciplinary environment and embrace learning about areas outside of your traditional area of expertise. You will identify and source new business opportunities with biotech and pharma through market research, networking, and by building business relationships to expand Inceptive’s network.

Key responsibilities include leading outbound BD efforts, including prospecting, relationship building, and pipeline management, as well as supporting deal execution (term sheets, negotiations, diligence, closing) and collaborating with scientific and technical teams to translate platform capabilities into partner value.

To succeed in this role, you will need a Master's in science (PhD preferred), ideally with a background in biologics, genetic medicines, or deep learning methods applied to drug development, and 3 years of experience in business development in pharma, biotech or VC.

The salary range for this position is $135K – $240K + Bonus + Equity.

XML job scraping automation by YubHub