In this dynamic role, you'll be responsible for providing medical leadership across the entire product lifecycle. You'll advise on Research & Development investment decisions, lead pre-launch scientific efforts, and accelerate evidence-based healthcare changes in the real world. Your networking and influencing skills will be key as you facilitate cross-functional collaboration and drive innovation.

Reporting to the Medical Head of Weight Management, the Senior GMAL is a highly experienced Medical Affairs leader with proven vision and impact. This individual develops and leads bold medical strategies within the obesity and cardiorenal-metabolic outcomes therapy area (specifically MASH, heart failure and CKD), expertly guiding cross-functional and cross-regional teams to deliver and exceed ambitious goals.

The Senior GMAL's influence is enterprise-wide,shaping global medical agendas through Global Medical Team, Global Product Team, and Disease Area Team leadership, and deep partnership with Medical and Commercial functions in markets and regions worldwide. This role demands a leader who champions innovative, disruptive thinking,identifies and shapes breakthrough opportunities, reimagines market dynamics, and accelerates high-impact evidence generation and medical change initiatives.

Key responsibilities include: Strategy & Transformation: Design and lead the implementation of product and disease area strategies, as well as ambitious practice change initiatives, at a global level. Medical Evidence Leadership: Own the evidence generation strategy, demonstrating advanced experience in clinical research, interventional trials (Phases 2–4), and real-world evidence (RWE) programs. Advanced Scientific & Digital Engagement: Blend scientific expertise with strong digital acumen, leveraging digital health tools, advanced analytics, and data platforms to transform evidence communication, personalize stakeholder engagement, and enhance patient outcomes. Guiding and Influencing Stakeholders: Build and sustain powerful relationships across the healthcare ecosystem, including global and regional KOLs, professional societies, regulators, payers, patient organizations, digital innovators, and health systems. Regulatory Insight & Compliance: Possess keen regulatory understanding and ensure clinical trial and evidence generation initiatives are designed for both scientific and regulatory success.

Essential qualifications include: Doctoral-level degree (MD, PhD, PharmD) Master’s degree with at least 5 years of experience in the pharmaceutical industry (Medical, Marketing, R&D, Market Access), or extensive experience within a health system (clinical, pharmacy, pathway design, etc.) Demonstrated leadership in complex, global healthcare environments, including leading franchise/TA business in key markets, driving brand performance, and managing large, diverse teams. Significant expertise and strategic insight into healthcare system pathways, regulatory landscapes, market-shaping, and external stakeholder engagement. Strong track record of internal and external network building, collaboration across geographies and matrix teams, and effective mentoring of junior colleagues or peers. Digital proficiency, leveraging digital health tools and data platforms to advance evidence generation and communication. Deep understanding of patient care pathways, evolving treatment protocols, scientific literature, and contemporary approaches to healthcare transformation. Proven ability to guide, influence, and align diverse stakeholders,including thought leaders, regulatory bodies, patient groups, and payer organisations.

Desirable qualifications include: Clinical experience in obesity, PCP, heart failure and/or CKD Experience with the USA health care system Recognised expertise in the relevant or related therapeutic area, often evidenced by a history of clinical practice, research leadership, or significant external engagement. Advanced experience designing, leading, and interpreting clinical research programs, including pivotal clinical trials (Ph2–Ph4), practice-changing RWE studies, and implementation of innovative evidence generation approaches. Broad experience beyond Medical Affairs; for example, prior roles in Marketing, R&D, or Market Access. Long-standing relationships with global KOLs, societies, regulators, digital health partners, and innovative healthcare organisations. Track record of launching new products or indications in multiple, diverse markets (e.g., US, China, EU), and successfully developing and executing global medical strategies.

Total Rewards: The annual base pay (or hourly rate of compensation) for this position ranges from $243,586 to $365,379. Our positions offer eligibility for various incentives,an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement plans.

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In this dynamic role, the Global Medical Head, Obesity for our injectables portfolio (SARA and GLP1/GCGR agonists) provides medical leadership across the entire product lifecycle. The role leads a team of talented medical professionals, advises on Research and Development investment decisions, drives pre-launch scientific efforts, and accelerates evidence-based healthcare changes in the real world. Networking and influencing skills are crucial to facilitate cross-functional collaboration and drive innovation.

Ready to take on this challenge? This highly experienced Medical Affairs leader brings validated vision and impact to shape product and disease area strategy, build capability, drive product launches and life cycle management, provide strategic direction for evidence generation, education and publication, and engage extensively externally to further the scientific leadership of AstraZeneca.

Reporting directly to the Medical Head of Weight Management and T2D within Medical Affairs Cardiovascular Renal Metabolism (CVRM), this critical strategic leadership position sits on global product and brand teams and leads a global medical team. A strong network with regions and countries will be developed, pairing unique medical expertise with insight from markets, healthcare professionals, patients and health systems to design and implement world-class medical strategies globally.

Through this leadership, the role helps build a world-class obesity capability within AstraZeneca, enabling outstanding product launches, practice-defining clinical studies, generation of real-world evidence, transformation of health systems and, ultimately, acceleration of population health.

Responsibilities

• Provide enterprise leadership by building and leading the global CVRM BPM obesity team, partnering with key stakeholders internally and externally to deliver an integrated medical strategy for the injectables portfolio.

• Set strategic vision and direction by developing, integrating and implementing global strategic medical plans that span early development through launch and life cycle management for SARA and GLP1/GCGR agonists.

• Drive external scientific engagement by defining and driving an ambitious engagement agenda with key external authorities, scientific societies, patient organisations and health system partners to shape healthcare practice in obesity.

• Lead launch excellence, performance management and life-cycle optimisation by defining clear benchmarks, identifying new opportunities in disease state understanding, and ensuring competitive, evidence-based medical plans that anticipate current and future needs.

• Develop evidence generation strategy across clinical development, real-world evidence and health economics to address unmet needs in obesity management, advise guidelines and support access decisions.

• Guide scientific communication, education and publication planning to ensure robust dissemination of data that advises clinical practice and positions AstraZeneca as a trusted scientific partner.

• Act as a key partner across Research and Development and Commercial functions to influence investment decisions, advise brand strategies and ensure alignment between scientific innovation and real-world medical practice.

• Champion cross-functional collaboration across geographies, enabling knowledge sharing, capability building and consistent execution of global medical strategies at regional and local levels.

Essential Skills/Experience

• Sophisticated Scientific Degree (MBBS, PharmD, PhD, or MD) or equivalent education with substantial clinical or research experience relevant to obesity or cardiometabolic disease.

• A minimum of 7 years of experience in the pharmaceutical industry, ideally in Medical Affairs, working at the country and global/regional level.

• Experience leading the global CVRM BPM obesity team, partnering with key stakeholders internally and externally.

• Experience with the development, integration, and implementation of strategic medical plans at a global level.

• Experience driving a bold external engagement agenda, forming strategic alliances and partnerships that can shape healthcare and best practices in the obesity therapy area.

• Experience driving innovation and setting key performance indicators (KPIs) to shape disease state understanding, surface new opportunities, and deliver strategic medical plans that are bold for current and future needs

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