We are seeking an Associate Director level, Quantitative Systems Pharmacology Disease Lead for our Drug Metabolism and Pharmacokinetics (DMPK) department.

Quantitative Systems Pharmacology (QSP) is a discipline that uses quantitative and mechanistic mathematical disease models to enhance the robustness and quality of decision-making from early research through clinical development. DMPK is a science-driven organization that drives the translational understanding of drug disposition and quantitative pharmacology to deliver transformational medicines with our partners.

The successful candidate will be responsible for integrating data and knowledge in a highly collaborative and multi-disciplinary environment to develop a deeper understanding of physiological systems and disease mechanisms with the goal of influencing target prioritization, modality evaluation, and delivering molecules with transformational potential into the clinic.

Role Responsibilities:

• Build and utilize QSP models of biological, physiological, and pathophysiological processes to evaluate a disease, its pathways and progression, as well as drug candidates and treatment modalities
• Work in close collaboration with biologists, clinicians, clinical pharmacologists, QSP and nonclinical modelers, and other partner line colleagues to inform research programs and improve our understanding of disease mechanisms
• Serve as a disease-area QSP lead, possessing or developing expertise in disease pathophysiology, biomarkers, clinical endpoints, as well as in key experimental methodologies and data
• Serve as QSP modeling & simulation point-of-contact on project teams to solve challenging problems in drug research; contribute to preclinical study design and mechanistic interpretation of data
• Develop and/or utilize state-of-the-art mathematical tools to gain insight into causal relationships between individual components of system-level and drug-level responses of drug-target-biomarker-disease-patient interaction
• Analyze and interpret complex data sets in the context of disease mechanisms and pathways
• Explore new opportunities to combine QSP with other analytical approaches and build synergies through collaboration with computational groups working in areas related to human genetics, functional genomics, and AI/ML
• Perform scientific rigor and biological suitability assessment of QSP models and methodologies through applying a context-driven verification & validation process

Basic Qualifications:

• PhD in Applied Mathematics, Engineering, Pharmaceutical Sciences, Systems Biology, or related disciplines with experience in the application of mathematical and statistical methods
• 2 or more years of experience in Pharma Life Science Biomedical industry developing and applying QSP approaches to drug discovery or development programs
• Experience working with the theory, principles, statistical aspects of mathematical modeling and simulation, including numerical methods, parameter estimation/optimization, ordinary differential equations (ODEs), and how these can be applied in the development of complex models of biological pathways and systems
• Computational experience with one or more modeling and simulation packages or programming languages (e.g., MATLAB, SimBiology, Julia, Python, C/C++)

Preferred Qualifications:

• Solid biological understanding of immunology and previous experience in applying mechanistic modeling to metabolic, inflammatory, or fibrotic diseases
• Experience summarizing, condensing, and translating outcomes of modeling and simulation analyses into knowledge and insights that can be clearly understood by project teams
• Experience working with Large Language Models (LLMs) and Agentic AI
• Demonstrated collaborative ways of working and ability to work successfully in matrix teams
• Ability to effectively communicate and interact with key stakeholders, medical professionals and senior leadership
• Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills
• Experience with the application of scientific machine learning (SciML) approaches to mechanistic modeling
• Experience integrating omics and/or other multi-modal data with mechanistic models

Benefits:

• Health care and other insurance benefits (for employee and family)
• Retirement benefits
• Paid holidays
• Vacation
• Paid caregiver/parental and medical leave

Salary: For new hires in this position in the US, the annual base salary ranges from $157,575 to $262,625, depending on location and experience.

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Responsibilities:

• Provide technical support for electrical systems, including power distribution, generators, motor control, and emergency systems.
• Lead assessments, investigations, and corrective actions for electrical incidents and audit findings.
• Support capital and maintenance projects by reviewing designs, performing technical risk assessments, and advising on constructability and handover to operations.
• Drive site compliance to electrical codes, engineering standards, and safety requirements.
• Work with service partners and contractors to plan and verify work quality, schedules, and performance against contracts.
• Maintain asset and documentation records and support the transition of projects into operations with clear procedures and training.
• Identify and implement improvements, design changes, or modification to automation/mechanical systems, equipment of procedures to support the business in the following established change control processes.
• Conduct site management monitoring tasks and site GEMBAs to ensure service partner and 3rd party contractor works are being carried out in compliance with national, local, and GSK standards.
• Manage improvement programs generated by various sources: Audit findings, CAPA, Engineering/EHS alerts, preventable disruptions, sustainability objectives.
• Execute site assessments against Engineering Policies and Standards in support of real estate due diligence at the site.
• Manage risk mitigation plans/actions in the risk management systems to ensure gaps from engineering assessments or with service delivery at sites are brought to acceptable levels (as low as reasonably practical).
• Lead investigations and mitigation plans at the site for significant service failures, critical/major audit findings, dispute resolution, and process improvements.
• Champion implementation of engineering standards and process improvement initiatives from RDES service towers into site delivery teams. Identify and implement areas for EHS risk reduction and environmental sustainability.
• Ensure compliance with Quality and Environmental Health and Safety (EHS) requirements and ensure that the Engineering activity is a safe place to work and ‘inspection ready’ at all times.

Basic Qualifications:

• Bachelor’s degree in electrical engineering or related technical field, or equivalent experience.
• Minimum 3 years’ experience supporting electrical facilities in an industrial or manufacturing environment.
• Working knowledge of electrical codes and safety practices relevant to industrial facilities.
• Experience with troubleshooting and maintenance practices for electrical equipment.
• Proven ability to work with contractors and cross-functional teams to deliver safe outcomes.
• Strong written and verbal communication skills and attention to detail.

Preferred Qualifications:

• Experience in a regulated industry or facilities that require strict audit readiness.
• Familiarity with computerized maintenance management systems (CMMS) for work orders and asset records.
• Experience with fire protection power systems, emergency power, or hazardous area electrical systems.
• Exposure to project engineering for capital improvements and equipment upgrades.
• Knowledge of industrial utility systems and building automation interfaces. Relevant professional certifications or ongoing technical training in electrical safety or project management.
• Relevant professional certifications or ongoing technical training in electrical safety or project management.

Work arrangement: This role is primarily on-site but is eligible to work remote one day a week. This may require some travel between regional sites may be required.

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The focus of this role is the launch of a new pharmaceutical product in an orphan oncology indication. Effectively resolving the high complexity and ambiguity in shorter than usual timelines is critical for a major asset and a best in-industry launch.

The Global Marketing Director, Oncology will be a core member of the Global Marketing Team, responsible for shaping and executing the global brand and launch strategy. Reporting to the Senior Director, Global Marketing, this individual will translate brand strategy into launch-ready commercial execution , campaign materials, HCP/KEE engagement models, and affiliate-facing tools and guidance , while building the foundational thinking for a potential later expansion into a larger indication.

Key Responsibilities

Launch Strategy & Execution

• Contribute to and evolve elements of the global brand and launch plan, translating the overarching brand strategy set with the Senior Director into actionable marketing programs and timelines.
• Co-lead the development of core global campaign materials , positioning, messaging architecture, HCP and patient-facing content, sales aids, and digital assets , ensuring scientific accuracy, medical/legal/regulatory (MLR) compliance, and consistency of brand voice.
• In partnership with the Strategy & Operations director, build and maintain the global launch readiness plan and toolkit, ensuring affiliates have the strategic rationale, materials, and training support needed for local adaptation and execution.

KEE & External Expert Engagement

• Manage the commercial dimension of interactions with Key External Experts (KEEs), including planning and running the Commercial Strategic Council (or equivalent advisory forum) to pressure-test brand strategy, messaging, and launch readiness.
• Build and maintain a network of relevant oncology/GIST KEEs, ensuring compliant, well-documented, and strategically purposeful engagement aligned with Medical Affairs activities.
• Synthesize KEE and advisory board input into actionable recommendations for brand strategy, campaign development, and affiliate guidance.

Affiliate & Cross-Functional Collaboration

• Serve as the primary Global Marketing point of contact for key affiliates (US, EU5, Japan, China + regions) on brand strategy, campaign materials, and launch execution , balancing global consistency with local market needs.
• Drive affiliate engagement strategy and input into affiliate operational planning.
• Partner closely with US colleagues in particular, leveraging (or building) deep understanding of US oncology launch dynamics, given the market's outsized commercial and precedent-setting importance.
• Collaborate cross-functionally with Medical Affairs, Market Access/Pricing, Regulatory, Global Insights & Analytics, and Commercial Operations to ensure integrated, launch-ready plans.
• Drive culture of trust, respect, transparency, and accountability.

Insights, Planning & Governance

• Manage relevant agency relationships (creative, medical education, market research) to ensure high-quality, on-time, on-budget deliverables.
• Track and report on launch KPIs and readiness milestones, proactively flagging risks and proposing mitigations.
• Partner with Insights to deliver Global Forecast aligned to strategy, generating recommended assumptions and strategic inputs.
• Elucidate required SG&A and commercial model to optimise asset performance in Global markets.
• Contribute to budget planning and resource allocation for assigned workstreams.

Candidate Profile

Basic Qualifications:

• Bachelor's degree required; MBA or advanced scientific/business degree preferred.
• 5 years of Marketing experience with at least one global launch is required , this does not need to be launch-leadership experience, but candidates should have played a substantive role on at least one oncology (ideally rare/specialty tumor) launch team, with exposure to the full pre-launch-to-launch lifecycle.
• Experience engaging external experts/KEEs in a commercial capacity (advisory boards, steering committees, congress engagement) is highly valued.
• Preferably 8–10+ years of relevant pharmaceutical/biotech marketing experience, including meaningful time in oncology and multiple launches.

Preferred Qualifications:

• Global or international marketing experience, including working with or through affiliates, is a strong plus.
• Prior US pharmaceutical marketing or launch experience strongly preferred.

Skills & Attributes

• High degree of self-direction: comfortable owning ambiguous, cross-functional workstreams without close supervision or a supporting team.
• Strong strategic thinking paired with hands-on executional rigor , equally comfortable shaping positioning and building campaign materials.
• Excellent stakeholder management and influencing skills, with credibility to engage senior leaders, external experts, and affiliate teams as a peer.
• Strong analytical and insight-synthesis capabilities; able to translate data and expert input into clear commercial recommendations.
• Excellent written and verbal communication skills, including comfort presenting to senior governance forums.
• Understanding of specialty oncology treatment landscapes is a plus, though not required.

What Success Looks Like

• A launch-ready brand strategy and materials suite delivered on time for the launch window.
• A well-functioning Commercial Strategic Council providing consistent, high-quality strategic input from KEEs.
• Strong alignment and satisfaction from US, EU5, Japan, and China affiliates on global materials, tools, and support.

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