Responsibilities include:

• Leading clinical execution of medium to high complexity studies with significant business impact
• Providing input to support development of protocol design documents
• Developing efficient protocols that maximize operational efficiency and trial quality
• Providing clinical input to data review processes and ensuring compliance with internal and external standards
• Managing and approving informed consent documents, protocol amendments, and study reports
• Serving as primary contact with external investigators and internal study teams
• Reviewing and reporting safety data and protocol deviations
• Acting as medical monitor on one or more clinical trials
• Using AI-enabled tools and analytics to support clinical data review and risk identification

Qualifications include:

• MD or equivalent
• Postgraduate training in Dermatology, Rheumatology, or Pulmonology
• 5+ years of experience in biopharmaceutical industry
• Demonstrated scientific productivity and clinical/medical expertise
• Experience with AI-enabled tools, automation, and digital clinical trial technologies

Benefits include:

• Competitive salary ($239,900 - $399,800 per year)
• Bonus target of 25% of base salary
• Eligibility to participate in share-based long-term incentive program
• Comprehensive benefits package, including 401(k) plan, paid vacation, and health insurance

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Responsibilities:

• Lead process discovery for oligonucleotide therapeutics, developing and troubleshooting SPOS routes from milligram to gram scale for ASOs, siRNA, SSO, and RNA editors with routine and next-generation amidite chemistries.
• Generate in vivo study material at rodent and NHP scale using an ÄKTA Oligosynt synthesizer, ensuring synthesis and purification strategies translate cleanly from discovery into larger-scale production.
• Develop and optimize chromatography and purification strategies that scale from milligram discovery quantities through gram-scale campaigns.
• Perform hands-on method development, establish oligo synthesis and purification workflows, and draft SOPs that bridge discovery chemistry and process/scale-up needs.
• Serve as the oligo synthesis and process discovery SME for the team, representing process chemistry in various cross-matrix meetings.
• Develop and maintain standard operating procedures (SOPs) for synthesis, processing, and purification to ensure high-quality, reproducible in vivo-grade material.
• Partner with the oligo analytical and conjugate chemistry teams to ensure accountability and excellence in oligonucleotide and conjugate synthesis.
• Collaborate and communicate across discovery, process, and analytical teams to build robust, scalable workflows and deliver on portfolio endpoints.

Requirements:

• PhD in chemistry, chemical biology, or a related field, with 2–4+ years of industry experience in oligonucleotide process chemistry, process discovery, or related synthesis/process roles.
• Hands-on experience with solid-phase oligonucleotide synthesis (SPOS) at milligram-to-gram scale, including method development, chromatography, and purification strategies that support larger-scale synthesis.
• General familiarity with mid-scale synthesizers, such as ÄKTA Oligosynt and Mermade12, ÄKTA Avant and Pure purification systems with Unicorn software, and LC/HRMS, UPLC, LC/MS analytics.
• Expertise in oligonucleotide synthesis (SPOS) and biological familiarity with RNA therapeutics (e.g. ASO, siRNA, SSO, RNA Editors), with the ability to generate in vivo rodent- and NHP-scale API0.

Preferred Qualifications:

• Minimum PhD with 4+ years of experience in oligonucleotide process chemistry, process discovery, oligo chemistry, or related fields.
• Direct experience generating in vivo study material (rodent and/or NHP scale) in a discovery or process development environment.
• Experience translating discovery-stage synthesis routes into larger-scale synthesis and purification strategies.
• Prior experience with scientific and professional mentorship and project management.
• Team-focused with strong initiative and ability to troubleshoot challenges and implement new solutions.
• Excellent written and verbal communication skills, attention to detail, organizational skills, and the ability to collaborate effectively with a team are required.
• Experience with oligonucleotide conjugation chemistries is desirable but not required.
• Sense of urgency, flexibility, independence and accountability.
• Ability to communicate both verbally and in writing with all levels both inside and outside of the organization.
• Maintain a high level of integrity while balancing multiple priorities and responsibilities.
• Must be a committed team player prepared to work in and embrace a team-based culture.

Location and Working Arrangement: This position is full-time and on-site in the United States. Specific site location will be shared during the application process. Candidates must be willing to work in a laboratory environment.

What we offer:

• Competitive salary: $121,275 to $202,125 per year
• Annual bonus and eligibility to participate in our share-based long-term incentive program
• Comprehensive benefits package, including health care and other insurance benefits, retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave

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This highly visible role provides strategic clinical, scientific, operational, and people leadership across a portfolio of complex clinical development programs.

The successful candidate will lead and develop a team of clinical scientists while ensuring oversight of clinical integrity, scientific quality, patient safety, and disciplined execution across studies within the Dermatology Franchise.

This leader will also help advance new ways of working, including the responsible integration of AI-enabled, digital, data, and advanced analytics capabilities to improve clinical development quality, speed, and decision-making.

As a senior change leader within a highly experienced matrix organization, this individual will bring strategic clarity, operational discipline, and collaborative influence to address portfolio challenges, optimize resource allocation, and scale effective solutions across the clinical trial lifecycle.

Key Responsibilities

Team Leadership & Change Management

• Lead, mentor, and develop a team of high-performing clinical scientists, fostering a culture of collaboration, accountability, continuous learning, intellectual curiosity, and agility.
• Act as a change champion, guiding a highly tenured organization through digital transformation and new ways of working.
• Drive change management initiatives that encourage the adoption of innovative tools and process optimizations without compromising scientific rigor.
• Build strong, collaborative partnerships with Clinical Operations, Data Science, Biostatistics, Digital/Technology, Regulatory, Medical Affairs, Portfolio Strategy, and Business Operations to align clinical science objectives with broader enterprise goals.
• Portfolio planning, lifecycle management, and evaluation of future growth opportunities.

Business Operations & Enterprise Strategy

• Apply strong business acumen to identify operational bottlenecks within clinical development and lead cross-functional workstreams to design and implement scalable solutions.
• Partner with cross-functional teams on enterprise initiatives to develop and implement fit-for-purpose operating practices, tools, and governance approaches that enable a well-controlled, flexible organization with strong fiscal management, cross-team communication, and efficient workflows.
• Establish and leverage standardized frameworks to evaluate clinical program designs, resource needs, and workflows through an operational efficiency lens, ensuring resources are optimized and key milestones are supported.
• Support generating business insights, metrics, and dashboards to inform decision-making, monitor therapeutic area performance, and identify opportunities to improve quality, speed, productivity, and portfolio impact.
• Navigate a complex matrix environment with an enterprise mindset, ensuring that innovation strategies in I&I can scale and align with broader Pfizer corporate objectives.

AI-Enabled Clinical Development & Innovation

• Partner closely with data science, digital, and technology teams to translate complex AI use cases into practical, scalable, compliant workflows for study teams.
• Lead the identification, strategic development, and implementation of AI/ML and advanced analytics tools to optimize clinical trial design and execution.
• Direct applied AI/ML approaches across the continuum, including protocol design and optimization, site selection and feasibility assessment, patient recruitment and enrollment strategies, query management and workflow automation, data cleaning, anomaly detection, and signal identification, safety risk prediction and proactive mitigation.
• Incorporate AI-derived insights and data-driven approaches into overarching clinical strategy and regulatory deliverables.

Core Clinical Leadership

• Oversee the clinical execution and integrity of a portfolio of high-complexity clinical studies within the I&I dermatology pipeline.
• Provide senior-level clinical oversight in protocol design, development, and strategic clinical documentation (protocols, CSRs, regulatory submissions).
• Oversee study delivery, quality, and operational excellence. Serve as a senior clinical escalation point and strategic partner for Product Team Leads, Global Development Leads, investigators, and internal study teams.
• Contribute to evaluation of external opportunities, business development assessments, or due diligence activities as needed, based on clinical expertise, therapeutic area knowledge, and project-specific needs.

Qualifications

Basic Qualifications

• Advanced scientific or clinical degree required; PhD, PharmD, or equivalent advanced degree strongly preferred.
• 10+ years of progressive clinical research and development experience in the pharmaceutical or biotechnology industry, including demonstrated experience supporting global clinical programs in regulated GxP environments.
• Proven people leadership experience with a track record of building, mentoring, developing, and inspiring high-performing clinical or cross-functional teams.
• Demonstrated ability to bridge clinical science with business operations, successfully leading cross-functional workstreams to solve complex operational challenges.
• Exceptional executive presence and communication skills, with the ability to influence without authority across all levels of a matrixed organization.

AI & Digital Expertise

• Demonstrated strategic or applied experience using AI, machine learning, automation, digital tools, or advanced analytics to improve clinical development, research, or operational workflows.
• Familiarity with AI-enabled clinical development use cases, such as protocol optimization, recruitment and enrollment planning, data review, query management, safety risk prediction, or workflow automation.
• Proven ability to partner with data science, digital, technology, clinical operations, bioinformatics, commercial, medical affairs, and other business stakeholders to define requirements, shape use cases, and support deployment of technical solutions.
• Strong understanding of data governance, model risk, compliance, privacy, and ethical AI considerations in pharmaceutical development.

Preferred Qualifications

• Demonstrated strategic experience applying AI, machine learning, automation, digital tools, or advanced analytics to optimize clinical development, research, or portfolio decision-making.
• Deep subject matter expertise in Inflammation & Immunology dermatology area.
• Direct experience leading organizational change management or digital transformation initiatives.
• Experience with real-world data, digital endpoints, and decentralized or innovative clinical trial technologies.
• Experience in portfolio strategy, resource planning, financial modeling, or business analytics.

Competencies for Success

• Enterprise Mindset: Demonstrates experience operating beyond a single study, function, or therapeutic area by connecting clinical science, portfolio priorities, operational execution, regulatory expectations, and enterprise business objectives. Makes decisions that optimize value for patients, the portfolio, and the broader organization.
• Change Agility: Brings a proven track record of leading teams through ambiguity, transformation, and new ways of working. Constructively challenges legacy processes, builds alignment across stakeholders, and translates change strategies into practical actions that improve quality, speed, and effectiveness.
• Digital Fluency: Demonstrates practical experience applying digital, data, AI/ML, automation, or advanced analytics capabilities to improve clinical development workflows. Partners effectively with technical teams, defines meaningful use cases, and ensures solutions are scalable, compliant, and adopted by end users.
• Balanced Judgment: Applies strong scientific, clinical, operational, and regulatory judgment when evaluating risks, trade-offs, and opportunities. Pursues innovation responsibly while safeguarding patient safety, data integrity, compliance, and scientific rigor.
• Emotional Intelligence: Demonstrates the interpersonal maturity, self-awareness, and influence skills required to lead in a complex matrix environment. Builds trust, listens actively, manages conflict constructively, and brings experienced colleagues along through change with credibility, empathy, and clarity.
• Drive for Results: Demonstrates a consistent record of setting ambitious goals, translating strategy into clear priorities, and delivering measurable outcomes in complex clinical development environments. Holds self and teams accountable, removes barriers, makes timely decisions, and drives disciplined execution while maintaining scientific rigor, patient focus, and compliance standards.

The annual base salary for this position ranges from $214,900.00 to $358,100.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 22.5% of the base salary and eligibility to participate in our share-based long-term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage.

Job Data by YubHub.

The successful candidate will partner with cross-functional teams to ensure data integrity and quality for clinical trials, and will be responsible for maintaining current scientific and clinical knowledge in the specific therapeutic area.

Key responsibilities include:

• Authoring and reviewing key clinical and regulatory documents
• Leading the clinical data review strategy and presenting relevant data to internal teams and stakeholders
• Collaborating with cross-functional team members to ensure trial objectives are met
• Providing scientific and clinical input for site training materials and supporting responses to investigator queries
• Ensuring compliance with relevant SOPs, regulations, and Good Clinical Practice (GCP)

The ideal candidate will have an advanced degree (PhD, PharmD, MS) in a relevant scientific discipline, with demonstrated experience in clinical development within the pharmaceutical/biotechnology industry.

In terms of qualifications and skills, we are looking for:

• Advanced degree (PhD, PharmD, MS) in a relevant scientific discipline
• Experience in clinical development within the pharmaceutical/biotechnology industry
• Strong understanding of the drug development process, clinical trial design, and execution
• Excellent knowledge of clinical procedures, ICH guidelines, and Good Clinical Practice (GCP)
• Proven scientific writing skills and strong verbal communication skills
• Ability to work collaboratively in a fast-paced, team-based matrix environment

This is a hybrid role requiring an average of two days of commuting per week.

The annual base salary for this position ranges from $139,100.00 to $231,900.00, with eligibility for participation in Pfizer's Global Performance Plan and share-based long-term incentive program.

Job Data by YubHub.

You will lead clinical protocol development and participate as an individual contributor on clinical study teams to support enrollment and study delivery timelines. You will work closely with cross-functional partners to ensure the full scope and perspective of I&I are represented within clinical study teams.

Responsibilities:

• Provide scientific leadership for the design, execution, and interpretation of clinical studies.
• Lead and support the development and execution of clinical development programs.
• Serve as a technical resource for clinical issues raised by internal and external collaborators.
• Support the development of publications, abstracts, presentations, and scientific communications.
• Participate on project teams to support clinical development strategy and study implementation.
• Lead preparation of clinical protocols and key study documents.
• Lead clinical data review activities.
• Collaborate with study teams to maintain open and transparent communication.
• Foster a transparent environment that encourages strong partnerships and mutual trust across teams.
• Develop effective partnerships with project leaders and cross-functional colleagues.
• Be accountable to multiple project teams and manage priorities.
• Develop expertise in Pfizer clinical processes and compliance systems.
• Partner with relevant functional lines to ensure biomarker strategies are incorporated into therapeutic area programs.
• Establish and maintain relationships with external experts and regulators.
• Maintain current knowledge of scientific and clinical literature relevant to I&I therapeutic areas.

Requirements:

• PhD/PharmD and 5+ years of relevant industry experience or MS and 7+ years or BSc and 8+ years of relevant industry experience.
• Deep understanding of the biopharmaceutical environment and clinical drug development.
• Experience developing and coaching others, guiding cross-functional teams, and driving meaningful business impact.
• Strong scientific writing, presentation, and verbal communication skills.
• Experience building consensus, influencing stakeholders, and driving change.
• Strong experience reviewing clinical data listings and interpreting study data.

Preferred Qualifications:

• Experience in Immunology clinical development.
• Experience supporting Phase 2, Phase 3, and/or late-stage clinical development programs.

Benefits:

• Comprehensive and generous benefits and programs.
• 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution.
• Paid vacation, holiday and personal days.
• Paid caregiver/parental and medical leave.
• Health benefits including medical, prescription drug, dental and vision coverage.

Salary: $176,600.00 - $294,300.00 per year. Bonus target: 20.0% of base salary. Eligibility to participate in Pfizer's share-based long-term incentive program.

Job Data by YubHub.