The successful candidate will serve in a matrix leadership role, partnering closely with DMPK, Medicinal Chemistry, Biology, and Clinical Pharmacology to enable early dose predictions and guide the design and selection of high-quality clinical candidates.

Responsibilities:

• Develop and apply fit-for-purpose mechanistic and translational models (PBPK, IVIVE, PK/PD) to guide drug discovery teams toward the highest-quality clinical candidates
• Translate complex ADME, PK, PD, and translational data into actionable insights for project teams and senior leadership
• Apply modeling expertise across diverse modalities, formulations, and routes of administration, including long-acting therapies
• Build scalable computational tools, workflows, and prototypes that accelerate discovery decisions and candidate optimization
• Establish best practices, standards, and governance for modeling methodologies, tools, and computational workflows
• Contribute to scientific publications, regulatory submissions, and other technical documentation, and represent ViiV externally through regulatory interactions and scientific thought leadership

Requirements:

• Master's degree with 7 or more years of post-graduate experience, or a PhD with 4 or more years of post-graduate experience, supporting drug discovery programs from lead optimization to Phase I clinical studies
• Strong understanding of ADME principles and integration of standard DMPK workflows and data streams into empirical and mechanistic modeling and simulation approaches
• Demonstrated ability to apply modeling and simulation approaches to influence key drug discovery decisions
• Broad computational programming expertise in programming and modeling languages (e.g., R, Python) and modeling platforms (e.g., Simcyp, GastroPlus)
• Experience integrating diverse datasets into unified predictive modeling platforms
• Ability to interpret and communicate modeling results to cross-functional teams

Preferred Qualifications:

• PhD with 6 or more years of drug discovery experience in DMPK or a related discipline
• Demonstrated experience developing and applying modeling and simulation strategies across diverse modalities and routes of administration
• Experience working across teams, including matrix and functional leadership
• Excellent written, verbal, and presentation skills
• Experience in infectious disease and/or immunology therapeutic areas

Benefits:

• Annual base salary ranging from $141,075 to $235,125
• Annual bonus and eligibility to participate in share-based long-term incentive program
• Health care and other insurance benefits
• Retirement benefits
• Paid holidays, vacation, and paid caregiver/parental and medical leave

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